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Evaluating the treatment outcomes of repetitive transcranial magnetic stimulation in patients with moderate-to-severe Alzheimer's disease
Zhang, Shouzi1; Liu, Lixin1; Zhang, Li1; Ma, Li1; Wu, Haiyan1; He, Xuelin1; Cao, Meng1; Li, Rui2,3
第一作者Shouzi Zhang
通讯作者邮箱lanczsz@163.com (shouzi zhang ) ; lir@psych.ac.cn (rui li )
心理所单位排序3
摘要

The repetitive transcranial magnetic stimulation (rTMS) shows great potential in the treatment of Alzheimer's disease (AD). However, its treatment efficacy for AD patients in moderate to severe stage is relatively evaluated. Here, we proposed a randomized, sham-controlled, clinical trial of rTMS among 35 moderate-to-severe AD patients. A high frequency (10 Hz) stimulation of the left dorsal lateral prefrontal cortex (DLPFC), 60-session long treatment lasting for 3 months procedure was adopted in the trial. Each participant completed a battery of neuropsychological tests at baseline and post-treatment for evaluation of the rTMS therapeutic effect. Twelve of them completed baseline resting-state functional magnetic resonance imaging (fMRI) for exploration of the underlying neural contribution to individual difference in treatment outcomes. The result showed that the rTMS treatment significantly improved cognitive performance on the severe impairment battery (SIB), reduced psychiatric symptoms on the neuropsychiatric inventory (NPI), and improved the clinician's global impression of change (CIBIC-Plus). Furthermore, the result preliminarily proposed resting-state multivariate functional connectivity in the (para) hippocampal region as well as two clusters in the frontal and occipital cortices as a pre-treatment neuroimaging marker for predicting individual differences in treatment outcomes. The finding could brought some enlightenment and reference for the rTMS treatment of moderate and severe AD patients.

关键词repetitive transcranial magnetic stimulation Alzheimer's disease functional magnetic resonance imaging individual difference intervention
2023-01-06
语种英语
DOI10.3389/fnagi.2022.1070535
发表期刊FRONTIERS IN AGING NEUROSCIENCE
ISSN1663-4365
卷号14页码:8
期刊论文类型实证研究
收录类别SCI
资助项目National Natural Science Foundation of China[62177004]
出版者FRONTIERS MEDIA SA
WOS关键词MILD COGNITIVE IMPAIRMENT ; CONNECTIVITY ; STATE ; CORTEX ; ASSOCIATION ; PLASTICITY ; GUIDELINES ; VALIDITY ; DECLINE ; MEMORY
WOS研究方向Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目Geriatrics & Gerontology ; Neurosciences
WOS记录号WOS:000914176000001
WOS分区Q1
资助机构National Natural Science Foundation of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://ir.psych.ac.cn/handle/311026/44655
专题中国科学院心理健康重点实验室
通讯作者Zhang, Shouzi; Li, Rui
作者单位1.Beijing Geriatr Hosp, Dept Psychiat, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
通讯作者单位中国科学院心理健康重点实验室
推荐引用方式
GB/T 7714
Zhang, Shouzi,Liu, Lixin,Zhang, Li,et al. Evaluating the treatment outcomes of repetitive transcranial magnetic stimulation in patients with moderate-to-severe Alzheimer's disease[J]. FRONTIERS IN AGING NEUROSCIENCE,2023,14:8.
APA Zhang, Shouzi.,Liu, Lixin.,Zhang, Li.,Ma, Li.,Wu, Haiyan.,...&Li, Rui.(2023).Evaluating the treatment outcomes of repetitive transcranial magnetic stimulation in patients with moderate-to-severe Alzheimer's disease.FRONTIERS IN AGING NEUROSCIENCE,14,8.
MLA Zhang, Shouzi,et al."Evaluating the treatment outcomes of repetitive transcranial magnetic stimulation in patients with moderate-to-severe Alzheimer's disease".FRONTIERS IN AGING NEUROSCIENCE 14(2023):8.
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