Relationships between clinical symptoms, cognitive functioning, and TMS-evoked potential features in patients with major depressive disorder

doi:10.1016/j.pnpbp.2024.111184

PSYCH OpenIR

	Relationships between clinical symptoms, cognitive functioning, and TMS-evoked potential features in patients with major depressive disorder
	Li, Jiaxin 1,2; Li, Xingxing 1,2,3; Liu, Junyao 1,2; Wei, Shuochi 1,2; Zhou, Dongsheng 3; Wang, Dongmei 1,2; Zhang, Xiangyang 1,2
通讯作者	Wang, Dongmei(wangdm@psych.ac.cn) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
摘要	Background: Cognitive impairment is a common clinical symptom of patients with major depressive disorder (MDD). Transcranial magnetic stimulation-evoked potentials (TEPs) detect cortical excitability and connectivity and provide potential biomarkers for MDD patients and their cognitive impairment. This study aimed to investigate the interrelationships between clinical symptoms, cognitive function, and electrophysiological marker TEPs in patients with MDD. Methods: A total of 117 participants were recruited, including 59 MDD patients and 58 healthy controls. Clinical symptoms were assessed by the Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale, and cognitive functioning was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). TEPs were recorded by transcranial magnetic stimulation combined with electroencephalography (TMS-EEG). Results: MDD patients exhibited lower RBANS total (P < 0.001), immediate memory (P = 0.001), language (P = 0.003), attention (P < 0.001), and delayed memory (P = 0.008) scores than HCs. Patients with MDD had larger amplitudes for N100 (P = 0.040) and N280 (P = 0.037), compared to HCs. Correlation analysis indicated significant correlations between the following RBANS scores and TEPs: language and N45 amplitude (r = 0.222, P = 0.024), language and P60 amplitude (r = 0.278, P = 0.004), attention and P180 amplitude (r = 0.213, P = 0.030), RBANS total score and P30 amplitude (r = 0.198, P = 0.044), visuospatial/constructional index and N100 amplitude (r = -0.272, P = 0.005). Conclusion: The results of this study indicate that cortical dysfunction and cognitive impairment are present in patients with MDD and that there is a strong correlation between them, suggesting that TEPs detected by the TMS-EEG may be used as a biomarker for MDD patients and their cognitive impairment.
关键词	Major depressive disorder Cognitive function TMS-EEG TMS-evoked potentials
	2025-01-10
语种	英语
DOI	10.1016/j.pnpbp.2024.111184
发表期刊	PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
ISSN	0278-5846
卷号	136 页码:7
收录类别	SCI
资助项目	STI2030-Major Projects[2021ZD0202102] ; Basic Public Welfare Project of Zhejiang Province[LGF22H090055] ; Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission[2019RC079] ; CAS Key Lab of Mental Health
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词	CORTICAL INHIBITION ; PREFRONTAL CORTEX ; EEG ; RTMS
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目	Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号	WOS:001366210300001
资助机构	STI2030-Major Projects ; Basic Public Welfare Project of Zhejiang Province ; Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission ; CAS Key Lab of Mental Health
引用统计
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/48745
通讯作者	Wang, Dongmei; Zhang, Xiangyang
作者单位	1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Ningbo Univ, Affiliated Kangning Hosp, Ningbo Kangning Hosp, Ningbo Key Lab Phys Diag & Treatment Mental & Psyc, Ningbo, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Li, Jiaxin,Li, Xingxing,Liu, Junyao,et al. Relationships between clinical symptoms, cognitive functioning, and TMS-evoked potential features in patients with major depressive disorder[J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,2025,136:7.
APA	Li, Jiaxin.,Li, Xingxing.,Liu, Junyao.,Wei, Shuochi.,Zhou, Dongsheng.,...&Zhang, Xiangyang.(2025).Relationships between clinical symptoms, cognitive functioning, and TMS-evoked potential features in patients with major depressive disorder.PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY,136,7.
MLA	Li, Jiaxin,et al."Relationships between clinical symptoms, cognitive functioning, and TMS-evoked potential features in patients with major depressive disorder".PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 136(2025):7.