COVID-19-related Olfactory Dysfunction: Prevalence, Mechanism and Recovery

doi:10.16476/j.pibb.2023.0055

	COVID-19-related Olfactory Dysfunction: Prevalence, Mechanism and Recovery
	Xing, Chen1,2 ; Ma, Jing-Chao1,2 ; Yun, Han-Qi 1,2; Liu, Qing-Jing1,2 ; Chang, Xiao-Yue 1,2; Wang, Yan-Qing 1,2; Zhou, Wen1,2,3
通讯作者	Zhou, Wen(zhouw@psych.ac.cn)
摘要	Coronavirus disease 2019 (COVID-19) is a global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since olfactory dysfunction is the main neurological symptom of COVID-19, it is important to examine the prevalence, underlying mechanisms, and recovery trajectories of COVID-19-related olfactory dysfunction for the promotion of public health. Reported prevalence rates of COVID19-related olfactory dysfunction vary widely across studies due to differences in the assessment of olfactory function, demographic background, and the predominant SARS-CoV-2 strains around the time of data collection. Specifically, different SARS-CoV-2 strains differ in the stability of spike glycoproteins and the host-cell infection pathways and thus efficacy in infecting the olfactory epithelium. In general, SARS-CoV-2 has been shown to cause inflammatory obstruction of the olfactory cleft, death of supporting cells, and host immune responses in the olfactory epithelium. Whether and how it invades into the central olfactory system remain controversial. Some individuals with "long COVID" suffer from chronic olfactory loss. The pathological mechanisms likely involve persistent inflammation in the olfactory epithelium and disruption of its regeneration triggered by SARS-CoV-2 infection. Based on the olfactory vector hypothesis, SARS-CoV-2 may affect central nervous system function by way of the olfactory system and could potentially induce neurodegeneration in the long term. Available interventions for managing olfactory dysfunction from SARS-CoV-2 infection include olfactory training and pharmacotherapy.
关键词	COVID-19 olfactory dysfunction SARS-CoV-2 SARS-CoV-2 variants long COVID olfactory training
	2023-06-01
语种	英语
DOI	10.16476/j.pibb.2023.0055
发表期刊	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN	1000-3282
卷号	50 期号:6 页码:1245-1260
收录类别	SCI
资助项目	Chinese Academy of Sciences[JCTD-2021-06] ; Institute of Psychology, Chinese Academy of Sciences[E0CX412008]
出版者	CHINESE ACAD SCIENCES, INST BIOPHYSICS
WOS关键词	NEURODEGENERATIVE DISEASE ; SARS-COV-2 INFECTION ; EPITHELIUM ; ROUTE
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:001021794700003
资助机构	Chinese Academy of Sciences ; Institute of Psychology, Chinese Academy of Sciences
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/45801
专题	脑与认知科学国家重点实验室
通讯作者	Zhou, Wen
作者单位	1.Chinese Acad Sci, Inst Psychol, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Chinese Inst Brain Res, Beijing 102206, Peoples R China
第一作者单位	脑与认知科学国家重点实验室
通讯作者单位	脑与认知科学国家重点实验室
推荐引用方式 GB/T 7714	Xing, Chen,Ma, Jing-Chao,Yun, Han-Qi,et al. COVID-19-related Olfactory Dysfunction: Prevalence, Mechanism and Recovery[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2023,50(6):1245-1260.
APA	Xing, Chen.,Ma, Jing-Chao.,Yun, Han-Qi.,Liu, Qing-Jing.,Chang, Xiao-Yue.,...&Zhou, Wen.(2023).COVID-19-related Olfactory Dysfunction: Prevalence, Mechanism and Recovery.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,50(6),1245-1260.
MLA	Xing, Chen,et al."COVID-19-related Olfactory Dysfunction: Prevalence, Mechanism and Recovery".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 50.6(2023):1245-1260.