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Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety | |
Chen, Zhiyi1,2,3; Tang, Yancheng4; Liu, Xuerong1; Li, Wei1; Hu, Yuanyuan5,6![]() ![]() ![]() | |
第一作者 | Chen, Zhiyi |
通讯作者邮箱 | chenzhiyi@tmmu.edu.cn ; zhouyuan@psych.ac.cn ; szqin@bnu.edu.cn ; fengty0@swu.edu.cn |
心理所单位排序 | 5 |
摘要 | Depression-anxiety comorbidity is commonly attributed to the occurrence of specific symptoms bridging the two disorders. However, the significant heterogeneity of most bridging symptoms presents challenges for psychopathological interpretation and clinical applicability. Here, we conceptually established a common bridging factor (cb factor) to characterize a general structure of these bridging symptoms, analogous to the general psychopathological p factor. We identified a cb factor from 12 bridging symptoms in depression-anxiety comorbidity network. Moreover, this cb factor could be predicted using edge-centric connectomes with robust generalizability, and was characterized by connectome patterns in attention and frontoparietal networks. In an independent twin cohort, we found that these patterns were moderately heritable, and identified their genetic connectome-transcriptional markers that were associated with the neurobiological enrichment of vasculature and cerebellar development, particularly during late-childhood-to-young-adulthood periods. Our findings revealed a general factor of bridging symptoms and its neurobiological architectures, which enriched neurogenetic understanding of depression-anxiety comorbidity. |
2024-12-04 | |
语种 | 英语 |
DOI | 10.1038/s41467-024-55008-0 |
发表期刊 | NATURE COMMUNICATIONS (IF:16.600[JCR-2022],17.000[5-Year]) |
卷号 | 15期号:1页码:15 |
期刊论文类型 | 综述 |
收录类别 | SCI |
资助项目 | National Natural Science Foundation of China (National Science Foundation of China)[32300907] ; National Natural Science Foundation of China (National Science Foundation of China)[32271123] ; National Natural Science Foundation of China[2022160258] ; PLA Talent Program Foundation[202211001] ; AMU-RD Scholar Foundation[CSTB2022TIADKPX0150] ; Key Projects for Technological Innovation and Application Development in Chongqing[2035] ; Key Projects for Technological Innovation and Application Development in Chongqing[SWUPilotPlan006] ; Innovation Research[2022YFC2705201] ; National Key Research and Development Program of China |
出版者 | NATURE PORTFOLIO |
WOS关键词 | RESEARCH DOMAIN CRITERIA ; HIERARCHICAL TAXONOMY ; NETWORK APPROACH ; DISORDERS ; CEREBELLUM ; EXPRESSION ; PATTERNS ; CONNECTIVITY ; MECHANISMS ; SCALE |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:001373784600005 |
WOS分区 | Q2 |
资助机构 | National Natural Science Foundation of China (National Science Foundation of China) ; National Natural Science Foundation of China ; PLA Talent Program Foundation ; AMU-RD Scholar Foundation ; Key Projects for Technological Innovation and Application Development in Chongqing ; Innovation Research ; National Key Research and Development Program of China |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://ir.psych.ac.cn/handle/311026/48732 |
专题 | 社会与工程心理学研究室 |
通讯作者 | Chen, Zhiyi; Zhou, Yuan; Qin, Shaozheng; Feng, Tingyong |
作者单位 | 1.Third Mil Med Univ, Expt Res Ctr Med & Psychol Sci, Sch Psychol, Chongqing, Peoples R China 2.Southwest Univ, Sch Psychol, Chongqing, Peoples R China 3.Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China 4.Shanghai Int Studies Univ, Sch Business & Management, Key Lab Brain Machine Intelligence Informat Behav, Minist Educ & Shanghai, Shanghai, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 7.Beijing Normal Univ, McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning & IDG, Beijing, Peoples R China 8.Sichuan Prov Peoples Hosp, Ctr Psychosomat Med, Sichuan Prov Ctr Mental Hlth, Chengdu, Peoples R China 9.Univ Elect Sci & Technol China, Clin Hosp, MOE Key Lab Neuroinformat, Chengdu Brain Sci Inst, Chengdu, Peoples R China 10.Shanghai Jiao Tong Univ, Global Inst Future Technol, Inst Psychol & Behav Sci, Ctr Brain Hlth & Brain Technol, Shanghai, Peoples R China |
通讯作者单位 | 中国科学院行为科学重点实验室 |
推荐引用方式 GB/T 7714 | Chen, Zhiyi,Tang, Yancheng,Liu, Xuerong,et al. Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety[J]. NATURE COMMUNICATIONS,2024,15(1):15. |
APA | Chen, Zhiyi.,Tang, Yancheng.,Liu, Xuerong.,Li, Wei.,Hu, Yuanyuan.,...&Feng, Tingyong.(2024).Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety.NATURE COMMUNICATIONS,15(1),15. |
MLA | Chen, Zhiyi,et al."Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety".NATURE COMMUNICATIONS 15.1(2024):15. |
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