消息
×
loading..
PSYCH OpenIR  > 社会与工程心理学研究室
Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety
Chen, Zhiyi1,2,3; Tang, Yancheng4; Liu, Xuerong1; Li, Wei1; Hu, Yuanyuan5,6; Hu, Bowen7; Xu, Ting2,8,9; Zhang, Rong2; Xia, Lei1; Zhang, Jing-Xuan1; Xiao, Zhibing7; Chen, Ji10; Feng, Zhengzhi1; Zhou, Yuan5,6; He, Qinghua2; Qiu, Jiang2; Lei, Xu2; Chen, Hong2; Qin, Shaozheng7; Feng, Tingyong2
第一作者Chen, Zhiyi
通讯作者邮箱chenzhiyi@tmmu.edu.cn ; zhouyuan@psych.ac.cn ; szqin@bnu.edu.cn ; fengty0@swu.edu.cn
心理所单位排序5
摘要

Depression-anxiety comorbidity is commonly attributed to the occurrence of specific symptoms bridging the two disorders. However, the significant heterogeneity of most bridging symptoms presents challenges for psychopathological interpretation and clinical applicability. Here, we conceptually established a common bridging factor (cb factor) to characterize a general structure of these bridging symptoms, analogous to the general psychopathological p factor. We identified a cb factor from 12 bridging symptoms in depression-anxiety comorbidity network. Moreover, this cb factor could be predicted using edge-centric connectomes with robust generalizability, and was characterized by connectome patterns in attention and frontoparietal networks. In an independent twin cohort, we found that these patterns were moderately heritable, and identified their genetic connectome-transcriptional markers that were associated with the neurobiological enrichment of vasculature and cerebellar development, particularly during late-childhood-to-young-adulthood periods. Our findings revealed a general factor of bridging symptoms and its neurobiological architectures, which enriched neurogenetic understanding of depression-anxiety comorbidity.

2024-12-04
语种英语
DOI10.1038/s41467-024-55008-0
发表期刊NATURE COMMUNICATIONS (IF:16.600[JCR-2022],17.000[5-Year])
卷号15期号:1页码:15
期刊论文类型综述
收录类别SCI
资助项目National Natural Science Foundation of China (National Science Foundation of China)[32300907] ; National Natural Science Foundation of China (National Science Foundation of China)[32271123] ; National Natural Science Foundation of China[2022160258] ; PLA Talent Program Foundation[202211001] ; AMU-RD Scholar Foundation[CSTB2022TIADKPX0150] ; Key Projects for Technological Innovation and Application Development in Chongqing[2035] ; Key Projects for Technological Innovation and Application Development in Chongqing[SWUPilotPlan006] ; Innovation Research[2022YFC2705201] ; National Key Research and Development Program of China
出版者NATURE PORTFOLIO
WOS关键词RESEARCH DOMAIN CRITERIA ; HIERARCHICAL TAXONOMY ; NETWORK APPROACH ; DISORDERS ; CEREBELLUM ; EXPRESSION ; PATTERNS ; CONNECTIVITY ; MECHANISMS ; SCALE
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:001373784600005
WOS分区Q2
资助机构National Natural Science Foundation of China (National Science Foundation of China) ; National Natural Science Foundation of China ; PLA Talent Program Foundation ; AMU-RD Scholar Foundation ; Key Projects for Technological Innovation and Application Development in Chongqing ; Innovation Research ; National Key Research and Development Program of China
引用统计
正在获取...
文献类型期刊论文
条目标识符https://ir.psych.ac.cn/handle/311026/48732
专题社会与工程心理学研究室
通讯作者Chen, Zhiyi; Zhou, Yuan; Qin, Shaozheng; Feng, Tingyong
作者单位1.Third Mil Med Univ, Expt Res Ctr Med & Psychol Sci, Sch Psychol, Chongqing, Peoples R China
2.Southwest Univ, Sch Psychol, Chongqing, Peoples R China
3.Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China
4.Shanghai Int Studies Univ, Sch Business & Management, Key Lab Brain Machine Intelligence Informat Behav, Minist Educ & Shanghai, Shanghai, Peoples R China
5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
7.Beijing Normal Univ, McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning & IDG, Beijing, Peoples R China
8.Sichuan Prov Peoples Hosp, Ctr Psychosomat Med, Sichuan Prov Ctr Mental Hlth, Chengdu, Peoples R China
9.Univ Elect Sci & Technol China, Clin Hosp, MOE Key Lab Neuroinformat, Chengdu Brain Sci Inst, Chengdu, Peoples R China
10.Shanghai Jiao Tong Univ, Global Inst Future Technol, Inst Psychol & Behav Sci, Ctr Brain Hlth & Brain Technol, Shanghai, Peoples R China
通讯作者单位中国科学院行为科学重点实验室
推荐引用方式
GB/T 7714
Chen, Zhiyi,Tang, Yancheng,Liu, Xuerong,et al. Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety[J]. NATURE COMMUNICATIONS,2024,15(1):15.
APA Chen, Zhiyi.,Tang, Yancheng.,Liu, Xuerong.,Li, Wei.,Hu, Yuanyuan.,...&Feng, Tingyong.(2024).Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety.NATURE COMMUNICATIONS,15(1),15.
MLA Chen, Zhiyi,et al."Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety".NATURE COMMUNICATIONS 15.1(2024):15.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Edge-centric connect(6890KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Zhiyi]的文章
[Tang, Yancheng]的文章
[Liu, Xuerong]的文章
百度学术
百度学术中相似的文章
[Chen, Zhiyi]的文章
[Tang, Yancheng]的文章
[Liu, Xuerong]的文章
必应学术
必应学术中相似的文章
[Chen, Zhiyi]的文章
[Tang, Yancheng]的文章
[Liu, Xuerong]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。