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Age-Related Changes in the Topological Organization of the White Matter Structural Connectome Across the Human Lifespan
Zhao, Tengda1,2,3; Cao, Miao1,2,3; Niu, Haijing1,2,3; Zuo, Xi-Nian3,4,5,6; Evans, Alan7; He, Yong1,2,3; Dong, Qi1,2,3; Shu, Ni1,2,3
2015-10-01
发表期刊HUMAN BRAIN MAPPING
ISSN1065-9471
文章类型Article
卷号36期号:10页码:3777-3792
摘要Lifespan is a dynamic process with remarkable changes in brain structure and function. Previous neuroimaging studies have indicated age-related microstructural changes in specific white matter tracts during development and aging. However, the age-related alterations in the topological architecture of the white matter structural connectome across the human lifespan remain largely unknown. Here, a cohort of 113 healthy individuals (ages 9-85) with both diffusion and structural MRI acquisitions were examined. For each participant, the high-resolution white matter structural networks were constructed by deterministic fiber tractography among 1024 parcellation units and were quantified with graph theoretical analyses. The global network properties, including network strength, cost, topological efficiency, and robustness, followed an inverted U-shaped trajectory with a peak age around the third decade. The brain areas with the most significantly nonlinear changes were located in the prefrontal and temporal cortices. Different brain regions exhibited heterogeneous trajectories: the posterior cingulate and lateral temporal cortices displayed prolonged maturation/degeneration compared with the prefrontal cortices. Rich-club organization was evident across the lifespan, whereas hub integration decreased linearly with age, especially accompanied by the loss of frontal hubs and their connections. Additionally, age-related changes in structural connections were predominantly located within and between the prefrontal and temporal modules. Finally, based on the graph metrics of structural connectome, accurate predictions of individual age were obtained (r=0.77). Together, the data indicated a dynamic topological organization of the brain structural connectome across human lifespan, which may provide possible structural substrates underlying functional and cognitive changes with age. (C) 2015 Wiley Periodicals, Inc.
关键词Brain Network Diffusion Mri Fiber Tractography Graph Theory Lifespan White Matter
收录类别SCI
语种英语
WOS记录号WOS:000364219100005
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/15322
专题中国科学院行为科学重点实验室
作者单位1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
3.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing 100875, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
5.Inst Psychol, Inst Psychol, Lab Funct Connectome & Dev, Beijing 100101, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
7.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ H3A 2B4, Canada
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Zhao, Tengda,Cao, Miao,Niu, Haijing,et al. Age-Related Changes in the Topological Organization of the White Matter Structural Connectome Across the Human Lifespan[J]. HUMAN BRAIN MAPPING,2015,36(10):3777-3792.
APA Zhao, Tengda.,Cao, Miao.,Niu, Haijing.,Zuo, Xi-Nian.,Evans, Alan.,...&Shu, Ni.(2015).Age-Related Changes in the Topological Organization of the White Matter Structural Connectome Across the Human Lifespan.HUMAN BRAIN MAPPING,36(10),3777-3792.
MLA Zhao, Tengda,et al."Age-Related Changes in the Topological Organization of the White Matter Structural Connectome Across the Human Lifespan".HUMAN BRAIN MAPPING 36.10(2015):3777-3792.
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