PSYCH OpenIR  > 中国科学院行为科学重点实验室
Age-Related Changes in the Topological Organization of the White Matter Structural Connectome Across the Human Lifespan
Zhao, Tengda1,2,3; Cao, Miao1,2,3; Niu, Haijing1,2,3; Zuo, Xi-Nian3,4,5,6; Evans, Alan7; He, Yong1,2,3; Dong, Qi1,2,3; Shu, Ni1,2,3
2015-10-01
Source PublicationHUMAN BRAIN MAPPING
ISSN1065-9471
SubtypeArticle
Volume36Issue:10Pages:3777-3792
AbstractLifespan is a dynamic process with remarkable changes in brain structure and function. Previous neuroimaging studies have indicated age-related microstructural changes in specific white matter tracts during development and aging. However, the age-related alterations in the topological architecture of the white matter structural connectome across the human lifespan remain largely unknown. Here, a cohort of 113 healthy individuals (ages 9-85) with both diffusion and structural MRI acquisitions were examined. For each participant, the high-resolution white matter structural networks were constructed by deterministic fiber tractography among 1024 parcellation units and were quantified with graph theoretical analyses. The global network properties, including network strength, cost, topological efficiency, and robustness, followed an inverted U-shaped trajectory with a peak age around the third decade. The brain areas with the most significantly nonlinear changes were located in the prefrontal and temporal cortices. Different brain regions exhibited heterogeneous trajectories: the posterior cingulate and lateral temporal cortices displayed prolonged maturation/degeneration compared with the prefrontal cortices. Rich-club organization was evident across the lifespan, whereas hub integration decreased linearly with age, especially accompanied by the loss of frontal hubs and their connections. Additionally, age-related changes in structural connections were predominantly located within and between the prefrontal and temporal modules. Finally, based on the graph metrics of structural connectome, accurate predictions of individual age were obtained (r=0.77). Together, the data indicated a dynamic topological organization of the brain structural connectome across human lifespan, which may provide possible structural substrates underlying functional and cognitive changes with age. (C) 2015 Wiley Periodicals, Inc.
KeywordBrain Network Diffusion Mri Fiber Tractography Graph Theory Lifespan White Matter
Indexed BySCI
Language英语
WOS IDWOS:000364219100005
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15322
Collection中国科学院行为科学重点实验室
Affiliation1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
3.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing 100875, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
5.Inst Psychol, Inst Psychol, Lab Funct Connectome & Dev, Beijing 100101, Peoples R China
6.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
7.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ H3A 2B4, Canada
Recommended Citation
GB/T 7714
Zhao, Tengda,Cao, Miao,Niu, Haijing,et al. Age-Related Changes in the Topological Organization of the White Matter Structural Connectome Across the Human Lifespan[J]. HUMAN BRAIN MAPPING,2015,36(10):3777-3792.
APA Zhao, Tengda.,Cao, Miao.,Niu, Haijing.,Zuo, Xi-Nian.,Evans, Alan.,...&Shu, Ni.(2015).Age-Related Changes in the Topological Organization of the White Matter Structural Connectome Across the Human Lifespan.HUMAN BRAIN MAPPING,36(10),3777-3792.
MLA Zhao, Tengda,et al."Age-Related Changes in the Topological Organization of the White Matter Structural Connectome Across the Human Lifespan".HUMAN BRAIN MAPPING 36.10(2015):3777-3792.
Files in This Item:
File Name/Size DocType Version Access License
Age-Related Changes (1197KB)期刊论文作者接受稿暂不开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhao, Tengda]'s Articles
[Cao, Miao]'s Articles
[Niu, Haijing]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhao, Tengda]'s Articles
[Cao, Miao]'s Articles
[Niu, Haijing]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhao, Tengda]'s Articles
[Cao, Miao]'s Articles
[Niu, Haijing]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.