Disrupted brain functional networks in patients with amblyopia: a resting-state fMRI study
Qian Li; Yue Yan; Huaiqiang Sun; Xubo Yang; Qiyong Gong; Longqian Liu
2016
会议名称2016年第一届北京视觉科学会议
会议日期2016-07
会议地点北京
摘要

PURPOSE: To explore the topological properties of brain functional networks derived from resting-state functional magnetic resonance imaging in patients with amblyopia.
METHODS: Seventeen amblyopic subjects and twenty control subjects were recruited to undergo a resting-state functional magnetic resonance imaging scan. The whole-brain functional networks were constructed for each subject, and topological properties such as small-worldness, network effciency and nodal centrality were quantitatively analyzed with graph theoretical analysis.
RESULTS: Both the amblyopic and control groups exhibited small-world properties in brain functional networks, which means a balance between local segregation and global integration for visual information processing. However, compared with control subjects, patients with amblyopia showed altered quantitative values of brain functional networks, characterized with decreased clustering coefficient, lower characteristic path length and decreased network effciency. Topological properties are also significantly altered in some brain regions. These alterations support the disrupted topological organization of brain functional networks in patients with amblyopia.
CONCLUSIONS: Amblyopia is partly resulted from the deficits of visual information transmission. Detection and estimation of altered brain functionl networks can help to further understand the pathophysiological mechanism underlying amblyopia.

会议主办者中国科学院心理研究所
学科领域感知觉心理学
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收录类别其他
语种英语
文献类型会议论文
条目标识符http://ir.psych.ac.cn/handle/311026/20812
专题心理所主办学术会议_2016年第一届北京视觉科学会议_会议摘要
作者单位1.Department of Ophthalmology, West China Hospital, Sichuan University, No.37 Guo Xue Xiang, Wuhou District, Chengdu, China, 610041
2.Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, No.37 Guo Xue Xiang, Wuhou District, Chengdu, China, 610041
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Qian Li,Yue Yan,Huaiqiang Sun,et al. Disrupted brain functional networks in patients with amblyopia: a resting-state fMRI study[C]. 见:2016年第一届北京视觉科学会议. 北京. 2016-07.http://vision.csp.escience.cn/dct/page/1.
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