Disrupted brain functional networks in patients with amblyopia: a resting-state fMRI study
Qian Li; Yue Yan; Huaiqiang Sun; Xubo Yang; Qiyong Gong; Longqian Liu
2016
Conference Name2016年第一届北京视觉科学会议
Conference Date2016-07
Conference Place北京
Abstract

PURPOSE: To explore the topological properties of brain functional networks derived from resting-state functional magnetic resonance imaging in patients with amblyopia.
METHODS: Seventeen amblyopic subjects and twenty control subjects were recruited to undergo a resting-state functional magnetic resonance imaging scan. The whole-brain functional networks were constructed for each subject, and topological properties such as small-worldness, network effciency and nodal centrality were quantitatively analyzed with graph theoretical analysis.
RESULTS: Both the amblyopic and control groups exhibited small-world properties in brain functional networks, which means a balance between local segregation and global integration for visual information processing. However, compared with control subjects, patients with amblyopia showed altered quantitative values of brain functional networks, characterized with decreased clustering coefficient, lower characteristic path length and decreased network effciency. Topological properties are also significantly altered in some brain regions. These alterations support the disrupted topological organization of brain functional networks in patients with amblyopia.
CONCLUSIONS: Amblyopia is partly resulted from the deficits of visual information transmission. Detection and estimation of altered brain functionl networks can help to further understand the pathophysiological mechanism underlying amblyopia.

Funding Organization中国科学院心理研究所
Subject Area感知觉心理学
URL查看原文
Indexed By其他
Language英语
Document Type会议论文
Identifierhttp://ir.psych.ac.cn/handle/311026/20812
Collection心理所主办、承办、协办学术会议_2016年第一届北京视觉科学会议_会议摘要
Affiliation1.Department of Ophthalmology, West China Hospital, Sichuan University, No.37 Guo Xue Xiang, Wuhou District, Chengdu, China, 610041
2.Huaxi MR Research Center, Department of Radiology, West China Hospital, Sichuan University, No.37 Guo Xue Xiang, Wuhou District, Chengdu, China, 610041
Recommended Citation
GB/T 7714
Qian Li,Yue Yan,Huaiqiang Sun,et al. Disrupted brain functional networks in patients with amblyopia: a resting-state fMRI study[C]. 见:2016年第一届北京视觉科学会议. 北京. 2016-07.http://vision.csp.escience.cn/dct/page/1.
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