PSYCH OpenIR  > 健康与遗传心理学研究室
Alternative TitleThe Conditioned Immunom.odulation with Electrical Stimulation as Conditioned Stimulus and the Neural Mechanism
Thesis Advisor林文娟
Degree Grantor中国科学院研究生院
Place of Conferral北京
Degree Discipline生物心理学
Keyword条件反射性抗体反应增强 电刺激 卵清白蛋白 阿片受体 M胆碱 能受体


Other Abstract

    It was previously shown that the enhancement of humoral immune function can be conditioned. However, only two kinds of conditioned stimulus, olfactory and gustatory, were used in those studies. Considering the generalization of conditioned enhancement of antibody production as well as the possibility of clinical application of conditioned immunoenhancement, the electrical stimulation (ES) was used as conditioned stimulus (CS). The conditioned immunoenhancement model was established by a single pairing of electrical stimulation with the injection of ovalbumin (UCS). The neural mechanisms underlying the conditioned antibody response using the ES as conditioned stimulus were also investigated. The main results are as follows:
   1 .Using the single CS/LJCS pairing paradigm, re-exposure of the animals to ES can sufficiently result in a large enhancement of anti-OVA antibody production. The elevation of antibody production can be observed at day 5 after the CS representation and achieved the peak at day 10, maintained to day 17, and declined at day 24.
    2. In learning stage of conditioning, anesthesia procedure could not block the elevation of conditioned antibo勿enhancement, indicating that using the ES as conditioned stimulus, the animals cam be conditioned unconsciously. No effect of ES on normal antibody production was found.
    3. For the expression of the conditioning effect, the normal function of central muscarinic receptor are required in the CS/UCS associative learning stage, wherESs the recall stage is central muscarinic receptor independent. No effect of scopolamine on normal unconditioned antibody production was found.
    4. The learning stage of conditioned antibody production enhancement is opioid receptor independent. However, the normal function of central opioid receptor is required in recall stage of conditioning. No effect of naltrexone on normal unconditioned antibody production was found.
    In conclusion, ES, a kind of somatosensory stimulation, can be used as conditioned stimulus and can oe paired with antigen injection to establish a conditioned antibody production enhancement model. The central muscarinic cholinergic system and opioid system are involved in conditioning process. They play differentially roles in the learning stage and recall stage.

Document Type学位论文
Recommended Citation
GB/T 7714
黄景新. 电刺激信号诱发的条件性免疫调节作用及其神经机制[D]. 北京. 中国科学院研究生院,2004.
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