PSYCH OpenIR  > 健康与遗传心理学研究室
Alternative TitleEstablishment and evaluation of rat model with syndrome of liver qi depression transforming into fire
赵振武; 顾丽佳; 郭蓉娟; 郭建友; 董洪坦
Source Publication中华中医药杂志


Other Abstract

Objective: To confirm the rat model with syndrome of liver qi depression transforming into fire induced by emotional stress through observing the behavior, water intake, body weight and r value of claw color. Methods: 45 rats were randomly divided into control group, model group and Danzhi Xiaoyao Powder (DXP) group. The rat models were evaluated according to the following aspects: ① The analysis of elevated plus maze test was used to understand the degree of anxiety of rats and verify the rat model be successful or not; ② The behavior, water intake, body weight and r value of claw color were observed and tested; ③ To speculate the symptoms by means of prescription and observe the regulation effect of DXP. Results: The OE% and OT% of rats in model group were decreased obviously compared with control group after 14 days of stress (P<0.01, P<0.05). Rats in model group were in a state of irritability, and showed the frequent behaviors of attacks, inquiry and modify (P<0.01), low body weight, incremental water intake (P<0.01), and high r values (P<0.01). There was significant regulation effect of DXP on the above performance of rats (P<0.01, P<0.05). Conclusion: The rat models with syndrome of liver qi depression transforming into fire were established by using uncertainty of empty bottle of water stress method. This method could be used to clone the rat model successfully based on the theory of ‘depressed anger for a long time might cause liver qi depression transforming into fire’.

Keyword行为学 肝郁化火证 丹栀逍遥散 模型
Indexed ByCSCD
Funding Organization国家自然科学基金课题(No.81273624) ; 北京中医药大学科研创新团队项目(No.2011-CXTD-23)~~
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Recommended Citation
GB/T 7714
赵振武,顾丽佳,郭蓉娟,等. 肝郁化火证大鼠模型的建立与评价[J]. 中华中医药杂志,2015,30(6):2050-2053.
APA 赵振武,顾丽佳,郭蓉娟,郭建友,&董洪坦.(2015).肝郁化火证大鼠模型的建立与评价.中华中医药杂志,30(6),2050-2053.
MLA 赵振武,et al."肝郁化火证大鼠模型的建立与评价".中华中医药杂志 30.6(2015):2050-2053.
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