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D-Ribose as a Contributor to Glycated Haemoglobin
Chen, Xixi1; Su, Tao1; Chen, Yao2; He, Yingge1; Liu, Ying1; Xu, Yong2; Wei, Yan1; Li, Juan3; He, Rongqiao1,4; Y.Wei; R. He
Source PublicationEBIOMEDICINE
Correspondent ;
AbstractGlycated haemoglobin (HbA1c) is the most important marker of hyperglycaemia in diabetes mellitus. We show that D-ribose reacts with haemoglobin, thus yielding HbA1c. Using mass spectrometry, we detected glycation of haemoglobin with D-ribose produces 10 carboxylmethyllysines (CMLs). The first-order rate constant of fructosamine formation for D-ribose was approximately 60 times higher than that for D-glucose at the initial stage. Zucker Diabetic Fatty (ZDF) rat, a common model for type 2 diabetes mellitus (T2DM), had high levels of D-ribose and HbA1c, accompanied by a decrease of transketolase (TK) in the liver. The administration of benfotiamine, an activator of TK, significantly decreased D-ribose followed by a decline in HbA1c. In clinical investigation, T2DM patients with high HbA1c had a high level of urine D-ribose, though the level of their urine D-glucose was low. That is, D-ribose contributes to HbA1c, which prompts future studies to further explore whether D-ribose plays a role in the pathophysiological mechanism of T2DM. (C) 2017 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
KeywordD-ribose HbA1c Type 2 diabetes mellitus Transketolase Benfotiamine
Indexed BySCI
Funding OrganizationNational Key Research and Development Program of China(2016YFC1305900 ; Beijing Municipal Science and Technology Project(Z161100000217141 ; 973-Project(2012CB911004) ; NSFC(31270868 ; Science and Technology Bureau of Luzhou: Molecular mechanism of diabetic nephropathy(2013-326) ; External Cooperation Program of BIC, CAS(20140909) ; 2016YFC1306300) ; Z161100000216137) ; 31670805)
WOS Research AreaGeneral & Internal Medicine ; Research & Experimental Medicine
WOS SubjectMedicine, General & Internal ; Medicine, Research & Experimental
WOS IDWOS:000417440500025
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorY.Wei; R. He
Affiliation1.Univ Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
2.Southwest Med Univ, Luzhou 646000, Sichuan, Peoples R China
3.Univ Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 100069, Peoples R China
Recommended Citation
GB/T 7714
Chen, Xixi,Su, Tao,Chen, Yao,et al. D-Ribose as a Contributor to Glycated Haemoglobin[J]. EBIOMEDICINE,2017,25(不详):143-153.
APA Chen, Xixi.,Su, Tao.,Chen, Yao.,He, Yingge.,Liu, Ying.,...&R. He.(2017).D-Ribose as a Contributor to Glycated Haemoglobin.EBIOMEDICINE,25(不详),143-153.
MLA Chen, Xixi,et al."D-Ribose as a Contributor to Glycated Haemoglobin".EBIOMEDICINE 25.不详(2017):143-153.
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