PSYCH OpenIR  > 健康与遗传心理学研究室
Thesis Advisor李娟
Degree Grantor中国科学院大学
Place of Conferral中国科学院心理研究所
Degree Name理学硕士
Degree Discipline健康心理学
Keyword亚临床抑郁老年人 海马/旁海马 灰质体积 情绪冲突 认知控制

本研究报告包括两个研究,第一个研究采用结构磁共振成像(structural MRI)技术考察了亚临床抑郁老年人大脑结构的改变,第二个研究则通过任务态功能磁共振成像((task fMRI)技术考察了亚临床抑郁老年人在处理情绪冲突时的大脑活动。



Other Abstract

There are two studies in this research report. By using structural MRI9 the first study explores whether there exist brain structural alternations in old adults with subthreshold depression. The second study employs the task fMRI to examine whether the brain activity of old adults with subthreshold depression dysfunctions in resolving emotional conflict.

In the first study a priori region of interest (ROI) including the bilateral hippocampi and parahippocampi was defined and a voxel-based morphometry analysis was conducted to investigate the structural alterations of the hippocampus/ parahippocampus and potential correlations between its volume and participants' self reported depressive symptoms in the elderly suffering from subthreshold depression. The results showed that elderly people with StD had substantially reduced volumes of the right parahippocampus compared with healthy age-matched controls. Moreover, the volumes of the hippocampus/parahippocampus were significantly correlated with participants' self reported depressive symptoms in StD. These results demonstrate that structural alterations of the hippocampus/parahippocampus may occur at an early stage of depression. Findings of the present study highlighted a relation between structural alterations of the hippocampus/parahippocampus and a precursor of major depression, the subthreshold depression, in older adults.

In the second study, a face-word Stroop task was used to investigate whether the brain activity of the elderly people with StD dysfunctions when resolving emotional conflicts. The behavioral results showed that both emotional and non-emotional distractors generated significant interference conflict in both groups. The old adults with StD did not demonstrate increased distractibility to either type of distractor and performed similarly to the healthy controls in both tasks. Concerning brain activity, the non-emotional task was processed similarly by both groups. however, the differences were striking during the resolution of emotional interference. Data-driven whole-brain analysis demonstrated that in dealing with the emotional interference, old adults with StD shown stronger activity in DLPFC, A.CC, visual extrastriate cortex, and DMN related areas compared with healthy controls. In addition, the incongruent-congruent RT of old adults with StD was significantly correlated with the signal changes of right middle frontal gyrus, right fusiform gyrus, right inferior parietal lobule, and left superior frontal gyrus in the emotional interference task. For healthy controls, the incongruent-congruent RT was significantly correlated with the signal changes of right anterior cingulate and right fusifonn gyrus and the incongruent-congruent accuracy was only correlated with signal changes of right anterior cingulate in the emotional task. These results showed that the brain functions of old adults with StD alters greatly.

Document Type学位论文
Recommended Citation
GB/T 7714
周会霞. 亚临床抑郁老年人大脑结构和功能改变的研究[D]. 中国科学院心理研究所. 中国科学院大学,2016.
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