PSYCH OpenIR  > 健康与遗传心理学研究室
Alternative TitleMorphine-induced compulsive phenotype in reward-seeking behavior study and the effect of stress
Thesis Advisor白云静
Degree Grantor中国科学院大学
Place of Conferral中国科学院心理研究所
Degree Name理学硕士
Degree Discipline应用心理学
Keyword阿片类药物 强迫性表型 奖赏寻求行为 急性应激



结果:1)吗啡和盐水前处理动物能够建立“灯光信号一电击惩罚”连接,面对惩罚信号提示以及惩罚时,盐水处理组动物会犹豫更长时间趋近奖赏或回避惩罚,而吗啡组会犹豫较短时间获得奖赏。2)只有少数吗啡戒断动物表现出明显的抗惩罚性,有效筛选出稳定的奖赏寻求行为强迫表型(试次完成率,zone 2,3停留时间等)。3)急性应激增加动物的强迫性奖赏寻求行为,应激当天不同表型个体之间仍然表现出稳定差异,应激后盐水组奖赏寻求行为恢复且有上升,而吗啡组有下降趋势。4)吗啡暴露不影响个体的性动机、痛觉感受阂限、电击敏感性以及恐惧记忆的获得和表达能力,且在不同表型之间没有显著差异。


Other Abstract

Objectives: Substance abuse is far-reaching to humans. The core diagnostic criteria for drug addiction are compulsive drugs seeking that do not count negative consequences. Moreover, clinical studies have found that there are large individual differences that exposure to addictive substances develops addiction. Through effective behavioral models, screening compulsive phenotypes and identifying factors of addiction are important for prevention and treatment of drug addiction. Because of the analgesic effect of opioids, it is not suitable for the pre-clinical compulsive drug seeking paradigm (foot-shock). The lack of good opioid-induced compulsive behavioral models has become a bottleneck in opioid addiction research. In addition, stress factors can affect a variety of psychological processes, and are important for maintaining and promoting compulsive behavior. Therefore, this study is aimed at constructing a compulsive reward seeking behavior model induced by opioids (morphine) in rats, screening compulsive phenotype individuals, and exploring the effects of acute stress on compulsive behavior.

Methods: In the conflict situation of high-value natural reward (sexual reward) and punishment (foot-shock), the study established a "light signal-foot shock" connection to distinguish the environmental safety. A stable compulsive reward seeking behavior model is established by examining the animal's reward seeking behavior in the face of prompting the punishment signal and being punished. Based on this, a stable compulsive phenotype was screened in morphine withdrawal rats. Finally, we investigated the effects of acute stress on reward seeking behaviors in different drug pretreatments or in different phenotypes of rats.

Results: 1) Morphine and saline pretreatment animals can establish a "light signal-foot shock" connection. In the face of punished signal and punishment, the saline-treated group will hesitate to approach the reward or avoid punishment in a longer time, while the morphine group will get rewards in a shorter time. 2) Only a small number of morphine withdrawal animals showed significant anti-punitiveness and can effectively screen out compulsive phenotypes (percentage of completed trials, time spent in zone 2, 3 etc.). 3) Acute stress increased the compulsive reward seeking behavior of animals. On the day of stress, different phenotypic individuals still showed stable differences. After the stress, the reward seeking behavior of the saline group animals recovered and increased, while the morphine group showed a downward trend. 4) Morphine exposure does not affect individual sexual motivation pain perception threshold, shock sensitivity, and ability to acquire and express fear memory, and there is no significant difference between different phenotypes.

Conclusion: This study successfully established a reliable and effective opioid (morphine)一induced compulsive reward seeking behavior model, and was able to screen out a stable forced phenotype, providing a new paradigm for studying the neurological mechanisms and susceptibility factors of opioid dependence. In addition acute stress can significantly promote compulsive reward seeking behavior.ence between different phenotypes.

Document Type学位论文
Recommended Citation
GB/T 7714
姜劲斐. 吗啡诱导大鼠奖赏寻求行为强迫性表型研究及应激的影响[D]. 中国科学院心理研究所. 中国科学院大学,2019.
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