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Abnormal Local Activity and Functional Dysconnectivity in Patients with Schizophrenia Having Auditory Verbal Hallucinations
Chen, Cheng1; Wang, Gao-hua1,2; Wu, Shi-hao1; Zou, Ji-lin1; Zhou, Yuan3,4; Wang, Hui-ling1,5
First AuthorChen, Cheng
Correspondent Emailhlwang@whu.edu.cn
Contribution Rank3
Abstract

Auditory verbal hallucination (AVH) is emphasized as a pathological hallmark of schizophrenia. Neuroimaging studies provide evidence linking AVH to overlapping functional abnormalities in distributed networks. However, no clear conclusion has still been reached. This study aimed to further explore the brain activity of patients with schizophrenia having AVH from both local activity (LA) and functional connectivity (FC) insights, while excluding confounding factors from other positive symptoms. A total of 42 patients with AVH (AVH patients group, APG), 26 without AVH (non-AVH patients group, NPG), and 82 normal controls (NC) underwent resting-state functional magnetic resonance imaging (fMRI). LA measures, including regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFF), and FC measures were evaluated to understand the neuroimaging mechanism of AVH. APG showed increased ReHo and fALFF in the bilateral putamen (Put) compared with NPG and NC. FC analysis (using bilateral putamen as seeds) revealed that all patients showed abnormal FC of multiple resting-state network regions, including the anterior and post cingulate cortex, middle frontal gyrus, inferior parietal gyrus, and left angular gyrus. Interestingly, APG showed significantly decreased FC of insula extending to the superior temporal gyrus and inferior frontal gyrus compared with NPG and NC. The present findings suggested a significant correlation of abnormal LA and dysfunctional putamen-auditory cortical connectivity with the neuropathological mechanism of AVH, providing evidence for the functional disconnection hypothesis of schizophrenia.

Keywordauditory verbal hallucination functional connectivity local activity resting-state functional magnetic resonance imaging schizophrenia
2020-10-01
Language英语
DOI10.1007/s11596-020-2271-4
Source PublicationCURRENT MEDICAL SCIENCE
ISSN2096-5230
Volume40Issue:5Pages:979-984
Subtype实证研究
Indexed BySCI
PublisherSPRINGER
WOS KeywordNETWORK ; CONNECTIVITY ; BRAIN ; FMRI ; STIMULATION ; LANGUAGE ; CORTEX
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000582907200023
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/33387
Collection中国科学院行为科学重点实验室
Corresponding AuthorWang, Hui-ling
Affiliation1.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430060, Peoples R China
2.Hubei Inst Neurol & Psychiat Res, Wuhan 430060, Peoples R China
3.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
5.Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R China
Recommended Citation
GB/T 7714
Chen, Cheng,Wang, Gao-hua,Wu, Shi-hao,et al. Abnormal Local Activity and Functional Dysconnectivity in Patients with Schizophrenia Having Auditory Verbal Hallucinations[J]. CURRENT MEDICAL SCIENCE,2020,40(5):979-984.
APA Chen, Cheng,Wang, Gao-hua,Wu, Shi-hao,Zou, Ji-lin,Zhou, Yuan,&Wang, Hui-ling.(2020).Abnormal Local Activity and Functional Dysconnectivity in Patients with Schizophrenia Having Auditory Verbal Hallucinations.CURRENT MEDICAL SCIENCE,40(5),979-984.
MLA Chen, Cheng,et al."Abnormal Local Activity and Functional Dysconnectivity in Patients with Schizophrenia Having Auditory Verbal Hallucinations".CURRENT MEDICAL SCIENCE 40.5(2020):979-984.
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