PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
脂多糖免疫激活导致抑郁性行为的动物研究:剂量和时程效应
Alternative TitleAnimal Research on Immunity Activation-Induced Depressive-Like Behavior:Doses and Time Effects
潘玉芹; 王东林; 林文娟
2007
Source Publication心理学报
ISSN0439-755X
Volume39Issue:6Pages:1041-1047
Abstract"抑郁症细胞因子假说"的提出为抑郁障碍的病因学研究提供了一个新的方向,为了探讨脂多糖(lipopo-lysaccharide,LPS)诱导的免疫激活与抑郁性行为产生之间的关系,本研究采用50只SD大鼠随机分为五组LPS400,LPS200,LPS50,LPS10,LPS0,分别于实验期第0天和第3天注入LPS400μg/kg,200μg/kg,50μg/kg,10μg/kg和生理盐水。以糖精水偏爱,旷场行为和高架十字迷宫评定大鼠LPS注射后2h,24h,48h的行为变化。结果显示一次LPS注射后2h,LPS50,LPS200,LPS400组动物与生理盐水组动物相比较,其糖精水偏爱分数(p<0.01),旷场中的水平活动距离(p<0.01)和直立行为(p<0.01)以及高架十字迷宫中的闭合臂进入次数(p<0.01)和开放臂进入次数显著下降(p<0.01);重复注射后2hLPS注射组动物的闭合臂进入次数显著降低(p<0.01);但LPS10组与生理盐水组动物在行为上没有差异,50μg/kg,200μg/kg和400μg/kg剂量的各组之间没有差异。LPS注射后24h和48h以及重复注射后大鼠的行为没有发现显著变化。...
Other AbstractThe "cytokine theory of depression" indicated that cytokines induced by immunity activity are not only immunity mediators but also play an important role in the mechanism of depressive-like behaviors. The administration of lipopolysaccharide (LPS), which is a product of the cell wall of Gram-negative bacteria, is known to activate immune functions and induce the release of several cytokines both in the periphery, and the brain such as frontal cortex, hippocampus, and hypothalamus that are considered to be t...
Keyword脂多糖 抑郁样行为 快感缺乏 自主活动
Subject Area生理心理学/生物心理学
Indexed ByCSCD
Language中文
Funding Project国家自然科学基金项目(NSF30670707)
CSCD IDCSCD:3134857
Citation statistics
Cited Times:5[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/3686
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding Author林文娟
Recommended Citation
GB/T 7714
潘玉芹,王东林,林文娟. 脂多糖免疫激活导致抑郁性行为的动物研究:剂量和时程效应[J]. 心理学报,2007,39(6):1041-1047.
APA 潘玉芹,王东林,&林文娟.(2007).脂多糖免疫激活导致抑郁性行为的动物研究:剂量和时程效应.心理学报,39(6),1041-1047.
MLA 潘玉芹,et al."脂多糖免疫激活导致抑郁性行为的动物研究:剂量和时程效应".心理学报 39.6(2007):1041-1047.
Files in This Item:
File Name/Size DocType Version Access License
脂多糖免疫激活导致抑郁性行为的动物研究_(695KB)期刊论文出版稿限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[潘玉芹]'s Articles
[王东林]'s Articles
[林文娟]'s Articles
Baidu academic
Similar articles in Baidu academic
[潘玉芹]'s Articles
[王东林]'s Articles
[林文娟]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[潘玉芹]'s Articles
[王东林]'s Articles
[林文娟]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 脂多糖免疫激活导致抑郁性行为的动物研究_剂量和时程效应.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.