PSYCH OpenIR  > 中国科学院心理研究所回溯数据库(1956-2010)
成瘾相关记忆的表观遗传学机制——药物成瘾研究的新视角
Alternative TitleEpigenetics: A Mechanism of Addictive Memory
李勇辉; 韩锦; 隋南
2008
Source Publication心理科学进展
ISSN1671-3710
Volume16Issue:3Pages:424-429
Abstract成瘾相关记忆长期性的脑机制一直是药物成瘾研究领域的难点与热点,该文简要介绍了成瘾记忆长期性分子机制的研究脉络,提示表观遗传学修饰可能是研究药物成瘾的新视角。成瘾药物可以调节染色体不同亚型组蛋白乙酰化水平,不同基因DNA的甲基化程度从而改变染色体的空间结构,进而调节基因的表达导致成瘾,特别是DNA甲基化改变的相对的稳定性可能是成瘾记忆长期存在的分子基础。记忆再巩固过程中学习记忆相关脑区的记忆促进基因与记忆抑制基因的表观遗传学改变可能是未来研究的新趋势。
Keyword药物成瘾 表观遗传学 组蛋白乙酰化 DNA甲基化
Subject Area医学心理学
Indexed By中文核心期刊要目总览 ASPT来源刊 CJFD收录刊
Language中文
Funding Project国家重点基础研究(973)项目(2003CB515404);; 国家自然基金面上项目(30600184);; 中国科学院心理研究所青年基金(07CX081008)项目
NotePersistent addictive memory has been one of the potential reasons to relapse. But the molecular mechanism of addictive memory is not clear. Epigenetic mechanism may be one of the potential substrates to keep the addictive memory persistent. And it has been established that drug of abuse can modify the chromatin structures through histone acetylation and DNA methylation, and further modulate gene expression underlying long-term neural plasticity. And the epigenetic mechanism of memory reconsolidation involve...
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/3768
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding Author隋南
Recommended Citation
GB/T 7714
李勇辉,韩锦,隋南. 成瘾相关记忆的表观遗传学机制——药物成瘾研究的新视角[J]. 心理科学进展,2008,16(3):424-429.
APA 李勇辉,韩锦,&隋南.(2008).成瘾相关记忆的表观遗传学机制——药物成瘾研究的新视角.心理科学进展,16(3),424-429.
MLA 李勇辉,et al."成瘾相关记忆的表观遗传学机制——药物成瘾研究的新视角".心理科学进展 16.3(2008):424-429.
Files in This Item:
File Name/Size DocType Version Access License
成瘾相关记忆的表观遗传学机制_药物成瘾研(770KB) 限制开放--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[李勇辉]'s Articles
[韩锦]'s Articles
[隋南]'s Articles
Baidu academic
Similar articles in Baidu academic
[李勇辉]'s Articles
[韩锦]'s Articles
[隋南]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[李勇辉]'s Articles
[韩锦]'s Articles
[隋南]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: 成瘾相关记忆的表观遗传学机制_药物成瘾研究的新视角.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.