Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis | |
Wang, Xin1; Xie, Hong2; Chen, Tian3; Cotton, Andrew S.1; Salminen, Lauren E.4; Logue, Mark W.5,6; Clarke-Rubright, Emily K.7,8; Wall, John2; Dennis, Emily L.4,9; O'Leary, Brian M.1; Abdallah, Chadi G.10,11; Andrew, Elpiniki12; Baugh, Lee A.13,14,15; Bomyea, Jessica16,17; Bruce, Steven E.18; Bryant, Richard19; Choi, Kyle20; Daniels, Judith K.21; Davenport, Nicholas D.22,23; Davidson, Richard J.24,25,26; DeBellis, Michael27; DeRoon-Cassini, Terri28; Disner, Seth G.22,23; Fani, Negar29; Fercho, Kelene A.13,14,15,30; Fitzgerald, Jacklynn31; Forster, Gina L.13,32; Frijling, Jessie L.33; Geuze, Elbert34,35; Gomaa, Hassaan36; Gordon, Evan M.37; Grupe, Dan25; Harpaz-Rotem, Ilan10,11; Haswell, Courtney C.7,8; Herzog, Julia I.38; Hofmann, David39; Hollifield, Michael40; Hosseini, Bobak41; Hudson, Anna R.42; Ipser, Jonathan43; Jahanshad, Neda4; Jovanovic, Tanja44; Kaufman, Milissa L.45,46; King, Anthony P.47; Koch, Saskia B. J.33,48; Koerte, Inga K.49,50; Korgaonkar, Mayuresh S.51; Krystal, John H.10,11; Larson, Christine52; Lebois, Lauren A. M.46,53; Levy, Ifat10,54; Li, Gen55,56; Magnotta, Vincent A.57,58,59; Manthey, Antje60,61,62,63; May, Geoffrey64,65,66,67; McLaughlin, Katie A.68; Mueller, Sven C.42,69; Nawijn, Laura33,70; Nelson, Steven M.64,65,66; Neria, Yuval71,72; Nitschke, Jack B.26; Olff, Miranda33,73; Olson, Elizabeth A.46,74; Peverill, Matthew75; Luan Phan, K.41,76,77; Rashid, Faisal M.4; Ressler, Kerry46,53; Rosso, Isabelle M.46,74; Sambrook, Kelly78; Schmahl, Christian38,79; Shenton, Martha E.46,49,80,81; Sierk, Anika60,61,62,63,82; Simons, Jeffrey S.15,83; Simons, Raluca M.14,83; Sponheim, Scott R.22,23; Stein, Murray B.17,84; Stein, Dan J.85,86; Stevens, Jennifer S.29; Straube, Thomas39; Suarez-Jimenez, Benjamin71,72; Tamburrino, Marijo1; Thomopoulos, Sophia I.4; van der Wee, Nic J. A.87,88; van der Werff, Steven J. A.87,88; van Erp, Theo G. M.89,90; van Rooij, Sanne J. H.29; van Zuiden, Mirjam33; Varkevisser, Tim34,35; Veltman, Dick J.70; Vermeiren, Robert R. J. M.91,92; Walter, Henrik60,61,62,63; Wang, Li56,93; Zhu, Ye55,56; Zhu, Xi71,72; Thompson, Paul M.4; Morey, Rajendra A.7,8; Liberzon, Israel67 | |
通讯作者 | Wang, Xin(xin.wang2@utoledo.edu) |
摘要 | Studies of posttraumatic stress disorder (PTSD) report volume abnormalities in multiple regions of the cerebral cortex. However, findings for many regions, particularly regions outside commonly studied emotion-related prefrontal, insular, and limbic regions, are inconsistent and tentative. Also, few studies address the possibility that PTSD abnormalities may be confounded by comorbid depression. A mega-analysis investigating all cortical regions in a large sample of PTSD and control subjects can potentially provide new insight into these issues. Given this perspective, our group aggregated regional volumes data of 68 cortical regions across both hemispheres from 1379 PTSD patients to 2192 controls without PTSD after data were processed by 32 international laboratories using ENIGMA standardized procedures. We examined whether regional cortical volumes were different in PTSD vs. controls, were associated with posttraumatic stress symptom (PTSS) severity, or were affected by comorbid depression. Volumes of left and right lateral orbitofrontal gyri (LOFG), left superior temporal gyrus, and right insular, lingual and superior parietal gyri were significantly smaller, on average, in PTSD patients than controls (standardized coefficients = -0.111 to -0.068, FDR corrected P values < 0.039) and were significantly negatively correlated with PTSS severity. After adjusting for depression symptoms, the PTSD findings in left and right LOFG remained significant. These findings indicate that cortical volumes in PTSD patients are smaller in prefrontal regulatory regions, as well as in broader emotion and sensory processing cortical regions. |
2020-12-07 | |
语种 | 英语 |
DOI | 10.1038/s41380-020-00967-1 |
发表期刊 | MOLECULAR PSYCHIATRY |
ISSN | 1359-4184 |
页码 | 13 |
收录类别 | SCI |
资助项目 | Anonymous Women's Health Fund ; Barlow Family Fund ; CDMRP[W81XWH-08-2-0038] ; Academic Medical Center Research Council[110614] ; BOF[01J05415] ; Center for Brain and Behavior Research Pilot Grant[CX001600 VA CDA] ; Dana Foundation ; DoD[W81XWH08-2-0159] ; DoD[W81XWH-10-1-0925] ; DoD[W81XWH-12-2-0012] ; DoD[F32MH109274] ; German Research Foundation[DA 1222/4-1] ; German Research Foundation[WA 1539/8-2] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[SFB/TRR 58] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[HD071982] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[HD085850] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[K01MH118428] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[K23MH090366-01] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[K24DA028773] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[K24MH71434] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[K99NS096116] ; Kasparian Fund[L30MH114379] ; Kasparian Fund[M01RR00039] ; Kasparian Fund[MH071537] ; Kasparian Fund[MH098212] ; Kasparian Fund[MH101380] ; Kasparian Fund[MJFF 14848] ; NARSAD- Young Investigator Grant ; National Institute of Child Health and Human Development[P30-HD003352] ; NCATS (CTSA)- Yale Center for Clinical Investigation ; Netherlands Organization for Health Research and Development[40-00812-98-10041] ; NHMRC Program Grant[1073041] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[P30HD003352] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[P41EB015922] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01AA12479] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01AG059874] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH043454] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH096987] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH103291] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH105355] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH105535] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH110483] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH111671] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH116147] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH117601] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH61744] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R01MH63407] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R21MH097196] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R21MH098198] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R21MH112956] ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol[R56AG058854] ; South African Medical Research Council ; South Dakota Governor's Research Center Grant[T32MH018931] ; Trauma Scholars Fund[U54EB020403] ; UCI-LBVA Biumvirate Grant[UL1TR000153] ; UCI-LBVA Biumvirate Grant[UL1TR000454] ; University of Wisconsin Institute for Clinical and Translational Research ; VA CSRD[1IK2CX001680] ; VA Merit Review Program ; VA National Center for PTSD ; VA[RRD1IK2RX000709] ; VA[RRD1K1RX002325] ; VA[RRD1K2RX002922] ; VA[RRDI01RX000622] ; VISN6 MIRECC ; [1R21MH102634] ; [5U01AA021681-08] |
出版者 | SPRINGERNATURE |
WOS关键词 | STRUCTURAL BRAIN ABNORMALITIES ; MAJOR DEPRESSIVE DISORDER ; VOXEL-BASED-MORPHOMETRY ; HIPPOCAMPAL VOLUME ; PREFRONTAL CORTEX ; MATTER REDUCTION ; METAANALYSIS ; CINGULATE ; INDIVIDUALS ; ASSOCIATION |
WOS研究方向 | Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry |
WOS类目 | Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry |
WOS记录号 | WOS:000598988400002 |
资助机构 | Anonymous Women's Health Fund ; Barlow Family Fund ; CDMRP ; Academic Medical Center Research Council ; BOF ; Center for Brain and Behavior Research Pilot Grant ; Dana Foundation ; DoD ; German Research Foundation ; German Research Society (Deutsche Forschungsgemeinschaft, DFG) ; Kasparian Fund ; NARSAD- Young Investigator Grant ; National Institute of Child Health and Human Development ; NCATS (CTSA)- Yale Center for Clinical Investigation ; Netherlands Organization for Health Research and Development ; NHMRC Program Grant ; NIAAA (P50)- Center for the Translational Neuroscience in Alcohol ; South African Medical Research Council ; South Dakota Governor's Research Center Grant ; Trauma Scholars Fund ; UCI-LBVA Biumvirate Grant ; University of Wisconsin Institute for Clinical and Translational Research ; VA CSRD ; VA Merit Review Program ; VA National Center for PTSD ; VA ; VISN6 MIRECC |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/38202 |
通讯作者 | Wang, Xin |
作者单位 | 1.Univ Toledo, Dept Psychiat, 2801 W Bancroft St, Toledo, OH 43606 USA 2.Univ Toledo, Dept Neurosci, 2801 W Bancroft St, Toledo, OH 43606 USA 3.Univ Toledo, Dept Math & Stat, 2801 W Bancroft St, Toledo, OH 43606 USA 4.Univ Southern Calif, Keck Sch Med, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA 5.VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA 6.Boston Univ, Dept Psychiat, Sch Med, Boston, MA 02215 USA 7.Duke Univ, Brain Imaging & Anal Ctr, Durham, NC USA 8.Durham VA Hlth Care Syst, VISN 6 MIRECC, Durham, NC USA 9.Univ Utah, Dept Neurol, Salt Lake City, UT USA 10.VA Connecticut Healthcare Syst, Natl Ctr PTSD, Clin Neurosci Div, West Haven, CT USA 11.Yale Univ, Dept Psychiat, Sch Med, New Haven, CT USA 12.Univ Sydney, Westmead, NSW, Australia 13.Univ South Dakota, Sanford Sch Med, Div Basic BioMed Sci, Vermillion, SD USA 14.Univ South Dakota, Ctr Brain & Behav Res, Vermillion, SD USA 15.Sioux Falls VA Hlth Care Syst, Sioux Falls, SD USA 16.VA San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, San Diego, CA USA 17.Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA 18.Univ Missouri, Ctr Trauma Recovery, Dept Psychol Sci, St. Louis, MO USA 19.Univ New South Wales, Sch Psychol, Sydney, NSW, Australia 20.Univ Calif San Diego, Hlth Serv Res Ctr, La Jolla, CA 92093 USA 21.Univ Groningen, Dept Clin Psychol, Groningen, Netherlands 22.Minneapolis VA Hlth Care Syst, Minneapolis, MN USA 23.Univ Minnesota, Dept Psychiat & Behav Sci, Minneapolis, MN USA 24.Univ Wisconsin, Ctr Hlth Minds, Madison, WI USA 25.Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA 26.Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA 27.Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA 28.Med Coll Wisconsin, Dept Surg, Div Trauma & Acute Care Surg, Milwaukee, WI USA 29.Emory Univ, Dept Psychiat & Behav Sci, Sch Med, Atlanta, GA 30322 USA 30.US Fed Avit Adm, Civil Aerosp Med Inst, Oklahoma City, 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USA 45.McLean Hosp, Div Womens Mental Hlth, Belmont, MA USA 46.Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA 47.Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA 48.Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Ctr Cognit Neuroimaging, Nijmegen, Netherlands 49.Brigham & Womens Hosp, Psychiat Neuroimaging Lab, 75 Francis St, Boston, MA 02115 USA 50.Ludwig Maximilians Univ Munchen, Dept Child & Adolescent Psychiat Psychosomat & Ps, Munich, Germany 51.Univ Sydney, Westmead Inst Med Res, Brain Dynam Ctr, Westmead, NSW, Australia 52.Univ Wisconsin, Dept Psychol, Milwaukee, WI 53201 USA 53.McLean Hosp, Div Depress & Anxiety Disorders, 115 Mill St, Belmont, MA 02178 USA 54.Yale Univ, Sch Med, Dept Comparat Med, New Haven, CT USA 55.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 56.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 57.Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA 58.Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA 59.Univ Iowa, Dept Biomed Engn, Iowa City, IA 52242 USA 60.Charite Univ Med Berlin, Berlin, Germany 61.Free Univ Berlin, Berlin, Germany 62.Humboldt Univ, Berlin, Germany 63.Berlin Inst Hlth, Berlin, Germany 64.Doris Miller VA Med Ctr, VISN 17 Ctr Excellence Res Returning War Vet, Waco, TX USA 65.Univ Texas Dallas, Ctr Vital Longev, Sch Behav & Brain Sci, Dallas, TX USA 66.Baylor Univ, Dept Psychol & Neurosci, Waco, TX 76798 USA 67.Texas A&M Univ, Dept Psychiat & Behav Sci, College Stn, TX USA 68.Harvard Univ, Dept Psychol, Boston, MA 02115 USA 69.Univ Deusto, Dept Personal, Psychol Assessment & Treatment, Bilbao, Spain 70.Univ Amsterdam, Locat Univ Med Ctr, Med Ctr, Dept Psychiat, Amsterdam, Netherlands 71.Columbia Univ, Dept Psychiat, Med Ctr, New York, NY USA 72.New York State Psychiat Inst & Hosp, New York, NY 10032 USA 73.ARQ Natl Psychotrauma Ctr, Diemen, Netherlands 74.McLean Hosp, Ctr Depress Anxiety & Stress Res, 115 Mill St, Belmont, MA 02178 USA 75.Univ Washington, Dept Psychol, Seattle, WA 98195 USA 76.Ohio State Univ, Wexner Med Ctr, Columbus, OH 43210 USA 77.Jesse Brown VA Med Ctr, Mental Hlth Serv Line, Chicago, IL USA 78.Univ Washington, Dept Radiol, Seattle, WA 98195 USA 79.Univ Western Ontario, Dept Psychiat, London, ON, Canada 80.VA Boston Healthcare Syst, Dept Psychiat, Brockton, MA USA 81.Harvard Med Sch, Dept Radiol, Boston, MA 02115 USA 82.UCL, Inst Cognit Neurosci, London, England 83.Univ South Dakota, Dept Psychol, Vermillion, SD USA 84.Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA 85.Univ Cape Town, SAMRC Unit Risk & Resilience Mental Disorders, Dept Psychiat, Cape Town, South Africa 86.Univ Cape Town, SAMRC Unit Risk & Resilience Mental Disorders, Neurosci Inst, Cape Town, South Africa 87.Leiden Univ, Dept Psychiat, Med Ctr, Leiden, Netherlands 88.Leiden Inst Brain & Cognit, Leiden, Netherlands 89.Univ Calif Irvine, Clin Translat Neurosci Lab, Dept Psychiat & Human Behav, Irvine, CA USA 90.Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA USA 91.Leiden Univ, Child & Adolescent Psychiat, Med Ctr, Leiden, Netherlands 92.Youz Parnassia Grp, Leiden, Netherlands 93.Chinese Acad Sci, Inst Psychol, Lab Traumat Stress Studies, CAS Key Lab Mental Hlth, Beijing, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Xin,Xie, Hong,Chen, Tian,et al. Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis[J]. MOLECULAR PSYCHIATRY,2020:13. |
APA | Wang, Xin.,Xie, Hong.,Chen, Tian.,Cotton, Andrew S..,Salminen, Lauren E..,...&Liberzon, Israel.(2020).Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis.MOLECULAR PSYCHIATRY,13. |
MLA | Wang, Xin,et al."Cortical volume abnormalities in posttraumatic stress disorder: an ENIGMA-psychiatric genomics consortium PTSD workgroup mega-analysis".MOLECULAR PSYCHIATRY (2020):13. |
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