中国科学院心理研究所机构知识库

目的初步研究感音神经性聋患者短纯音刺激失匹配负波(mismatch negativity,MMN)的变化特征。方法采用美国32导Neuroscan EEG/ERP记录系统对24例(48耳)听力正常受试者和7例(14耳)感音神经性聋患者进行MMN测试。采用经典Oddball模式,标准刺激和偏差刺激分别为500Hz和1000Hz的短纯音测试两组受试者MMN,比较两组MMN潜伏期和波幅的差异。结果感音神经性聋组MMN潜伏期为145.00±16.11ms,与对照组130.45±7.31ms相比,明显延长(P=0.009),两组的波幅改变无统计学意义(P=0.908)。而两组的波幅变异系数(CV%)均大于对应潜伏期的变异系数(CV%)。结论感音神经性聋患者MMN的潜伏期明显延长,波幅变化不大。MMN潜伏期相对比较稳定,但波幅个体间差异较大。

Objective To investigate the characteristics of mismatch negativity in sensorineural hearing loss （SNHL） patients. Methods Mismatch negativity（MMN） was recorded from 7 aduhs（14 ears） with hearing impairment and 24 normal hearing aduhs（48 ears） using American 32 channel Neuroscan EEC-/ERP system. The standard （500 Hz tone burst） and deviant stimuli（1 000 Hz tone burst） were presented in an oddball paradigm and the MMN were recorded under a passive listening condition. The latencies and amplitudes of the two groups were compared. Results The peak latency of MMN in the SNHL group was 145.00± 16.11 ms, which was significantly longer than that of 130.45±7.31 ms in the control group （P=0. 009）. In comparison with the control group,the MMN amplitude was unchanged in the SNHL group（P=0. 908）. Conclusion The latency of MMN in SNHL group is significantly longer than that of the control group, but the amplitude changes slightly. The latency of MMN is relatively stable, bul the amplitude of MMN is variable among individuals.

北京市自然科学基金(7062019) 北京市教育委员会科技发展计划面上项目(KM200710025020) 高等学校博士学科点专项科研基金(20060025002) 北京市科技新星计划(B类)2004-B-31 北京市自然科学基金(7082026)资助