Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium

doi:10.1038/s41380-019-0631-x

PSYCH OpenIR

	Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium
	Dennis, Emily L.1,2,3,4; Disner, Seth G.5,6; Fani, Negar 7; Salminen, Lauren E.2; Logue, Mark 8,9,10,11; Clarke, Emily K.12,13; Haswell, Courtney C.12,13; Averill, Christopher L.14,15; Baugh, Lee A.16,17,18; Bomyea, Jessica 19,20; Bruce, Steven E.21; Cha, Jiook 22,23; Choi, Kyle 24; Davenport, Nicholas D.5,6; Densmore, Maria 25,26; du Plessis, Stefan 27; Forster, Gina L.16,17,28; Frijling, Jessie L.29; Gonenc, Atilla 30,31; Gruber, Staci 30,31; Grupe, Daniel W.32; Guenette, Jeffrey P.33; Hayes, Jasmeet 34; Hofmann, David 35; Ipser, Jonathan 36,37; Jovanovic, Tanja 7,38; Kelly, Sinead 1,39; Kennis, Mitzy 40,41; Kinzel, Philipp 1,42; Koch, Saskia B. J.29,43; Koerte, Inga 1,42; Koopowitz, Sheri 36,37; Korgaonkar, Mayuresh 44; Krystal, John 14,15; Lebois, Lauren A. M.31,45; Li, Gen 46,47; Magnotta, Vincent A.48,49,50; Manthey, Antje 51; May, Geoff J.52,53,54,55; Menefee, Deleene S.56,57; Nawijn, Laura 29,58; Nelson, Steven M.52,53,55; Neufeld, Richard W. J.25,59,60,61; Nitschke, Jack B.62; O'Doherty, Daniel 63; Peverill, Matthew 64; Ressler, Kerry J.7,31,43; Roos, Annerine 65; Sheridan, Margaret A.66; Sierk, Anika 51; Simmons, Alan 19,20; Simons, Raluca M.17,67; Simons, Jeffrey S.18,67; Stevens, Jennifer 7; Suarez-Jimenez, Benjamin 22,23; Sullivan, Danielle R.8,9; Theberge, Jean 25,26,68; Tran, Jana K.69; van den Heuvel, Leigh 27; van der Werff, Steven J. A.70,71; van Rooij, Sanne J. H.7; van Zuiden, Mirjam 29; Velez, Carmen 3,72,73; Verfaellie, Mieke 9,74; Vermeiren, Robert R. J. M.70; Wade, Benjamin S. C.3,72,73,75; Wager, Tor 76; Walter, Henrik 51; Winternitz, Sherry 31,77; Wolff, Jonathan 45; York, Gerald 78,79; Zhu, Ye 46,47; Zhu, Xi 22,23; Abdallah, Chadi G.14,15; Bryant, Richard 80; Daniels, Judith K.81; Davidson, Richard J.32,62,82; Fercho, Kelene A.16,17,18,83; Franz, Carol 20,84; Geuze, Elbert 40,41; Gordon, Evan M.52,53,55; Kaufman, Milissa L.31,77; Kremen, William S.19,20,84; Lagopoulos, Jim 63; Lanius, Ruth A.25,26,60; Lyons, Michael J.85; McCauley, Stephen R.86,87,88; McGlinchey, Regina 31,89,90; McLaughlin, Katie A.91; Milberg, William 31,92; Neria, Yuval 22,23; Olff, Miranda 29,92; Seedat, Soraya 65; Shenton, Martha 1,93; Sponheim, Scott R.5,6; Stein, Dan J.36,37; Stein, Murray B.20,94; Straube, Thomas 35; Tate, David F.3,72,73; van der Wee, Nic J. A.70,71; Veltman, Dick J.58; Wang, Li 46,47; Wilde, Elisabeth A.3,88,95; Thompson, Paul M.2; Kochunov, Peter 96; Jahanshad, Neda 2; Morey, Rajendra A.12,13
通讯作者	Dennis, Emily L.(emily.dennis@hsc.utah.edu)
摘要	A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3047 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1426 individuals with PTSD and 1621 controls (2174 males/873 females) between ages 18-83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen's d = -0.11, p = 0.0055). The tapetum connects the left and right hippocampus, for which structure and function have been consistently implicated in PTSD. Results were consistent even after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network.
	2021-08-01
语种	英语
DOI	10.1038/s41380-019-0631-x
发表期刊	MOLECULAR PSYCHIATRY
ISSN	1359-4184
卷号	26 期号:8 页码:4315-4330
收录类别	SCI
资助项目	CIHR ; CIMVHR ; Dana Foundation ; University of Wisconsin Institute for Clinical and Translational Research ; National Science Foundation Graduate Research Fellowship[R01MH043454] ; National Science Foundation Graduate Research Fellowship[T32MH018931] ; National Institute of Child Health and Human Development[P30HD003352] ; Defense and Veterans Brain Injury Centers ; U.S. Army Medical Research and Materiel Command (USAMRMC)[W81XWH-13-2-0025] ; Chronic Effects of Neurotrauma Consortium (CENC)[PT108802-SC104835] ; Department of Defense[W81XWH-12-2-0012] ; NIH from the Big Data to Knowledge (BD2K) program[U54EB020403] ; NIH from the Big Data to Knowledge (BD2K) program[R56AG058854] ; NIH from the Big Data to Knowledge (BD2K) program[R01MH116147] ; NIH from the Big Data to Knowledge (BD2K) program[R01MH111671] ; NIH from the Big Data to Knowledge (BD2K) program[P41EB015922] ; Department of Veterans Affairs ; NIAAA ; NCATS ; DoD[W81XWH-101-0925] ; Center for Brain and Behavior Research Pilot Grant ; South Dakota Governor's Research Center Grant[F32MH109274] ; Bill & Melinda Gates Foundation ; SAMRC Unit on Risk & Resilience in Mental Disorders ; German Research Foundation grant[1222/4-1] ; German Research Foundation grant[1539/8-2] ; German Research Society (Deutsche Forschungsgemeinschaft, DFG)[SFB/TRR 58] ; Clinical Science Research and Development Service, VA Office of Research and Development[MH098212] ; Clinical Science Research and Development Service, VA Office of Research and Development[MH071537] ; Clinical Science Research and Development Service, VA Office of Research and Development[M01RR00039] ; Clinical Science Research and Development Service, VA Office of Research and Development[UL1TR000454] ; Clinical Science Research and Development Service, VA Office of Research and Development[HD071982] ; Clinical Science Research and Development Service, VA Office of Research and Development[HD085850] ; Clinical Science Research and Development Service, VA Office of Research and Development[MH101380] ; NARSAD[27040] ; NARSAD[K01MH109836] ; Young Investigator Grant, Korean Scientists and Engineers Association ; NHMRC Program[R01MH111671] ; NHMRC Program[1073041] ; NHMRC Program[R01AG050595] ; NHMRC Program[R01AG022381] ; NHMRC Program[R01AG058822] ; NHMRC Program[R01EB015611] ; NHMRC Program[R01MH105355] ; NHMRC Program[R01DA035484] ; NHMRC Program[R01MH117601] ; NHMRC Program[R01AG059874] ; NHMRC Program[MJFF 14848] ; NHMRC Program[VISN6 MIRECC] ; NHMRC Program[R21MH112956] ; Anonymous Women's Health Fund ; Kasparian Fund ; Trauma Scholars Fund ; Barlow Family Fund ; South African Medical Research Council[MRC-RFA-IFSP01-2013/SHARED ROOTS] ; South African National Treasury under its Economic Competitiveness and Support Package ; South African Medical Research Council through its Division of Research Capacity Development under the SAMRC CLINICIAN RESEARCHER (M.D PHD) SCHOLARSHIP PROGRAMME from the South African National Treasury ; South African Research Chairs Initiative in Posttraumatic Stress Disorder through the Department of Science and Technology ; National Research Foundation ; National Natural Science Foundation of China[31271099] ; National Natural Science Foundation of China[31471004] ; Research Program of the Chinese Academy of Sciences[ZDRW-XH-2019-4] ; ZonMw ; Netherlands organization for Health Research and Development[4000812-98-10041] ; Academic Medical Center Research Council[110614] ; Translational Research Center for TBI and Stress Disorders (TRACTS) ; VA Rehabilitation Research and Development (RR&D) Traumatic Brain Injury Center of Excellence at VA Boston Healthcare System[B9254-C] ; VA CSRD[1IK2CX001680] ; VISN17 Center of Excellence Pilot funding ; VA RRD[1IK2RX000709] ; VA RRD[1K1RX002325] ; VA RRD[1K2RX002922] ; VA RRD[I01RX000622] ; CDMRP from the US Department of Defense[W81XWH-08-2-0038] ; CDMRP from the US Department of Defense[W81XWH08-2-0159] ; [K99NS096116] ; [I01-CX000715] ; [I01-CX001542] ; [K01MH118428] ; [K23MH090366] ; [K2CX001772]
出版者	SPRINGERNATURE
WOS关键词	SMALLER HIPPOCAMPAL VOLUME ; FRACTIONAL ANISOTROPY ; STRUCTURAL INTEGRITY ; NEUROTROPHIC FACTOR ; TRACT INTEGRITY ; ABNORMALITIES ; CONNECTIVITY ; COMORBIDITY ; PREVALENCE ; MULTISITE
WOS研究方向	Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
WOS类目	Biochemistry & Molecular Biology ; Neurosciences ; Psychiatry
WOS记录号	WOS:000731712800056
资助机构	CIHR ; CIMVHR ; Dana Foundation ; University of Wisconsin Institute for Clinical and Translational Research ; National Science Foundation Graduate Research Fellowship ; National Institute of Child Health and Human Development ; Defense and Veterans Brain Injury Centers ; U.S. Army Medical Research and Materiel Command (USAMRMC) ; Chronic Effects of Neurotrauma Consortium (CENC) ; Department of Defense ; NIH from the Big Data to Knowledge (BD2K) program ; Department of Veterans Affairs ; NIAAA ; NCATS ; DoD ; Center for Brain and Behavior Research Pilot Grant ; South Dakota Governor's Research Center Grant ; Bill & Melinda Gates Foundation ; SAMRC Unit on Risk & Resilience in Mental Disorders ; German Research Foundation grant ; German Research Society (Deutsche Forschungsgemeinschaft, DFG) ; Clinical Science Research and Development Service, VA Office of Research and Development ; NARSAD ; Young Investigator Grant, Korean Scientists and Engineers Association ; NHMRC Program ; Anonymous Women's Health Fund ; Kasparian Fund ; Trauma Scholars Fund ; Barlow Family Fund ; South African Medical Research Council ; South African National Treasury under its Economic Competitiveness and Support Package ; South African Medical Research Council through its Division of Research Capacity Development under the SAMRC CLINICIAN RESEARCHER (M.D PHD) SCHOLARSHIP PROGRAMME from the South African National Treasury ; South African Research Chairs Initiative in Posttraumatic Stress Disorder through the Department of Science and Technology ; National Research Foundation ; National Natural Science Foundation of China ; Research Program of the Chinese Academy of Sciences ; ZonMw ; Netherlands organization for Health Research and Development ; Academic Medical Center Research Council ; Translational Research Center for TBI and Stress Disorders (TRACTS) ; VA Rehabilitation Research and Development (RR&D) Traumatic Brain Injury Center of Excellence at VA Boston Healthcare System ; VA CSRD ; VISN17 Center of Excellence Pilot funding ; VA RRD ; CDMRP from the US Department of Defense
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/41898
通讯作者	Dennis, Emily L.
作者单位	1.Brigham & Womens Hosp, Psychiat Neuroimaging Lab, Dept Psychiat, 75 Francis St, Boston, MA 02115 USA 2.USC, Imaging Genet Ctr, Stevens Neuroimaging & Informat Inst, Keck Sch Med, Marina Del Rey, CA 90292 USA 3.Univ Utah, Dept Neurol, Salt Lake City, UT 84112 USA 4.Stanford Neurodev Affect & Psychopathol Lab, Stanford, CA 94305 USA 5.Minneapolis VA Hlth Care Syst, Minneapolis, MN USA 6.Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA 7.Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA 8.VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA 9.Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA 10.Boston Univ, Sch Med, Biomed Genet, Boston, MA 02118 USA 11.Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA 12.Duke Univ, Brain Imaging & Anal Ctr, Durham, NC USA 13.Durham VA, VISN 6 MIRECC, Durham, NC USA 14.Yale Univ, Sch Med, Natl Ctr PTSD, Clin Neurosci Div, New Haven, CT USA 15.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA 16.Univ South Dakota, Sanford Sch Med, Div Basic Biomed Sci, Vermillion, SD USA 17.Univ South Dakota, Ctr Brain & Behav Res, Vermillion, SD USA 18.Sioux Falls VA Hlth Care Syst, Sioux Falls, SD USA 19.VA San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, La Jolla, CA USA 20.Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA 21.Univ Missouri, Dept Psychol Sci, Ctr Trauma Recovery, St Louis, MO 63121 USA 22.Columbia Univ, Dept Psychiat, Med Ctr, New York, NY USA 23.New York State Psychiat Inst & Hosp, New York, NY 10032 USA 24.Univ Calif San Diego, Hlth Serv Res Ctr, San Diego, CA 92103 USA 25.Western Univ, Dept Psychiat, London, ON, Canada 26.Lawson Hlth Res Inst, Imaging Div, London, ON, Canada 27.Stellenbosch Univ, Dept Psychiat, Stellenbosch, South Africa 28.Univ Otago, Brain Hlth Res Ctr, Dept Anat, Dunedin 9054, New Zealand 29.Univ Amsterdam, Amsterdam Univ Med Ctr, Locat Acad Med Ctr, Dept Psychiat,Amsterdam Neurosci, Amsterdam, Netherlands 30.McLean Hosp, Cognit & Clin Neuroimaging Core, 115 Mill St, Belmont, MA 02178 USA 31.Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA 32.Univ Wisconsin, Ctr Hlth Minds, Madison, WI USA 33.Brigham & Womens Hosp, Div Neuroradiol, 75 Francis St, Boston, MA 02115 USA 34.Ohio State Univ, Dept Psychol, Columbus, OH USA 35.Univ Munster, Inst Med Psychol & Syst Neurosci, Munster, Germany 36.Univ Cape Town, Dept Psychiat, SA Med Res Council Unit Risk & Resilience Mental, Cape Town, South Africa 37.Univ Cape Town, Neurosci Inst, Cape Town, South Africa 38.Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI USA 39.Harvard Med Sch, Dept Psychiat, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA 40.UMCU, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht, Netherlands 41.Minist Def, Brain Res & Innovat Ctr, Utrecht, Netherlands 42.Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Child & Adolescent Psychiat, Psychosomat & Psychotherapy, Munich, Germany 43.Radboud Univ Nijmegen, Ctr Cognit Neuroimaging, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands 44.Univ Sydney, Brain Dynam Ctr, Westmead Inst Med Res, Westmead, NSW, Australia 45.McLean Hosp, Div Depress & Anxiety Disorders, 115 Mill St, Belmont, MA 02178 USA 46.Chinese Acad Sci, Inst Psychol, Lab Traumat Stress Studies, CAS Key Lab Mental Hlth, Beijing, Peoples R China 47.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 48.Univ Iowa, Dept Radiol, Iowa City, IA USA 49.Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA 50.Univ Iowa, Dept Biomed Engn, Iowa City, IA 52242 USA 51.Univ Med Ctr Charite, Berlin, Germany 52.VISN 17 Ctr Excellence Res Returning War Vet, Waco, TX USA 53.Baylor Univ, Dept Psychol & Neurosci, Waco, TX 76798 USA 54.Texas A&M Hlth Sci Ctr, Dept Psychiat & Behav Sci, Bryan, TX USA 55.Univ Texas Dallas, Ctr Vital Longev, Sch Behav & Brain Sci, Dallas, TX USA 56.Baylor Coll Med, Menninger Dept Psychiat, Houston, TX 77030 USA 57.South Cent MIRECC, Houston, TX USA 58.Vrije Univ Amsterdam, Amsterdam Univ Med Ctr, Locat VU Univ Med Ctr, Dept Psychiat, Amsterdam, Netherlands 59.Western Univ, Dept Psychol, London, ON, Canada 60.Western Univ, Dept Neurosci, London, ON, Canada 61.Univ British Columbia, Dept Psychol, Okanagan, BC, Canada 62.Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA 63.Univ Sunshine Coast, Birtinya, Qld, Australia 64.Univ Washington, Dept Psychol, Seattle, WA 98195 USA 65.Stellenbosch Univ, South African Med Res Council, Dept Psychiat, Genom Brain Disorders Res Unit, Cape Town, South Africa 66.Univ N Carolina, Dept Psychol & Brain Sci, Chapel Hill, NC 27515 USA 67.Univ South Dakota, Dept Psychol, Vermillion, SD USA 68.Western Univ, Dept Med Biophys, London, ON, Canada 69.Houston Fire Dept, Houston, TX USA 70.LUMC, Dept Psychiat, Leiden, Netherlands 71.Leiden Inst Brain & Cognit, Leiden, Netherlands 72.Missouri Inst Mental Hlth, St Louis, MO USA 73.VA Boston Healthcare Syst, Boston, MA USA 74.VA Boston Healthcare Syst, Memory Disorders Res Ctr, Boston, MA USA 75.Univ Calif Los Angeles, Dept Neurol, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90024 USA 76.Dartmouth Coll, Hanover, NH 03755 USA 77.McLean Hosp, Div Womens Mental Hlth, 115 Mill St, Belmont, MA 02178 USA 78.Joint Trauma Syst, 3698 Chambers Pass, Ft Sam Houston, TX USA 79.Alaska Radiol Associates, Anchorage, AK USA 80.Univ New South Wales, Sch Psychol, Sydney, NSW, Australia 81.Univ Groningen, Dept Clin Psychol, Groningen, Netherlands 82.Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA 83.US Fed Aviat Adm, Civil Aerosp Med Inst, Oklahoma City, OK USA 84.Univ Calif San Diego, Ctr Behav Genet Aging, La Jolla, CA 92093 USA 85.Boston Univ, Dept Psychol & Brain Sci, Boston, MA 02215 USA 86.Boston Univ, Dept Neurol, Boston, MA 02215 USA 87.Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA 88.Baylor Coll Med, H Ben Taub Dept Phys Med & Rehabil, Houston, TX 77030 USA 89.VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Boston, MA USA 90.VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders, Boston, MA USA 91.Harvard Univ, Dept Psychol, 33 Kirkland St, Cambridge, MA 02138 USA 92.ARQ Natl Psychotrauma Ctr, Diemen, Netherlands 93.VA Boston Healthcare Syst, Brockton Div, Brockton, MA USA 94.Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA 95.George E Whalen Vet Affairs Med Ctr, Salt Lake City, UT USA 96.Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Baltimore, MD 21201 USA
推荐引用方式 GB/T 7714	Dennis, Emily L.,Disner, Seth G.,Fani, Negar,et al. Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium[J]. MOLECULAR PSYCHIATRY,2021,26(8):4315-4330.
APA	Dennis, Emily L..,Disner, Seth G..,Fani, Negar.,Salminen, Lauren E..,Logue, Mark.,...&Morey, Rajendra A..(2021).Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.MOLECULAR PSYCHIATRY,26(8),4315-4330.
MLA	Dennis, Emily L.,et al."Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium".MOLECULAR PSYCHIATRY 26.8(2021):4315-4330.