心理干预对围手术期乳腺癌患者情绪、自评健康及免疫功能的影响研究

PSYCH OpenIR > 中国科学院心理研究所回溯数据库(1956-2010)

	心理干预对围手术期乳腺癌患者情绪、自评健康及免疫功能的影响研究
其他题名	Effects of Psychological Intervention on Emotion，Subjective Health and Immunity Function in Perioperation Patients with Breast Cancer
	杨秀木
	2008-06-04
摘要	Objective：Developing a generalized psychological intervention program, and explore its influence on the emotion, subjective health, and immunity function of the perioperation patients with breast cancer. Method：Sixty patients with breast cancer were randomly divided into intervention and control groups. The clinical psychological intervention was performed on patients in the intervention group for 20 days, in addition to the routine therapy and care. Levels of emotion (SAS & SDS), subjective health (SF-36), and immunity function (t lymphocyte subsets) of the patients were tested. Results: 1.There was no significant difference between the age, income, educational level, and type of prefession of the two groups. There was no significant difference between SAS, SDS, SF-36 and lymphocyte subsets（CD3+, CD4+, CD8+, CD4+/CD8+, NK） of the two groups. 2. Scores of SAS and SDS decreased significantly after intervention in experimental group, while the score of SF-36, the average value of CD4+, CD4+/CD8+, and NK increased significantly. For the control group, the score of depression decreased significantly after intervention, while the score of PF, GH, VT, SF, RE, and MH increased significantly. 3. In comparison of the intervention and control group, the intervention effect of SAS, SDS, SF-36 scores (except SF), CD3+, CD4+, CD4+/CD8+, and NK differed significantly, with the priority of experimental group. 4. SDS, SAS, and CD3+, CD4+, NK correlated in negative respectively, while SDS, SAS, and CD8+ correlated in positive. PF, RP, GH, SF, and MH of subjective health correlated in positive with every index of immunity function in positive, except negative correlation with CD4+/CD8+. BP, RE correlated with CD3+,CD4+,CD8+, and NK in positive. VT correlated in positive with CD3+, CD8+, and NK, in negative with CD4+/CD8+. Conclusions: 1. Anxiety, depression, and subjective health, correlated with immunity function in perioperation patients with breast cancer. 2. Psychological intervention can improve the emotional status, subjective health, and immune function of patients with breast cancer to the optimum in perioperative period.; 目的：建立一个心理干预模式，对围手术期乳腺癌患者进行综合性心理干预，研究该模式对乳腺癌患者焦虑、抑郁、自评健康状况和免疫功能的影响。方法：将入选的60例围手术期乳腺癌患者按照对等匹配原则分成实验组组和控制组，每组30例。实验组患者接受20天的综合性心理干预，控制组患者给予常规护理。两组患者均于入院第2天、出院前1天填写焦虑自评量表（SAS）、抑郁自评量表（SDS）和自评健康状况问卷（SF-36），同时测量外周血T淋巴细胞亚群（CD3+、CD4+、CD8+、CD4+/CD8+、NK）各项指标。结果： 1．干预前组间比较：实验组和控制组患者的年龄、经济水平、受教育程度和职业等一般临床资料无显著性差异；两组患者干预前的焦虑、抑郁、自评健康状况的得分及T淋巴细胞亚群（CD3+、CD4+、CD8+、CD4+/CD8+、NK）数值比较差异不显著，两组患者具有可比性。 2．干预后组内自身比较：实验组患者干预前后纵向比较，SDS得分、SAS得分、SF-36各个维度得分、免疫指标的CD4+、CD4+/CD8+和NK的数值比较，差异显著。控制组患者干预前后纵向比较，SDS得分、SF-36的PF、GH、VT、SF、RE、MH六个维度的得分比较，差异显著。 3．干预后组间比较：干预后两组焦虑、抑郁状况均有所改善，但实验组改善更明显，两组差异显著；干预后实验组和控制组健康状况各项均有所提高，但是实验组提高更明显，自评健康状况的RP、BP、RE三项得分两组比较差异显著；干预后实验组CD3+、CD4+、NK细胞数值升高，CD4+/CD8+比值提高，CD8+数值有所下降，控制组各项指标变化不明显，CD4+、CD4+/CD8+、NK数值两组比较差异显著。 4．相关分析：SDS、SAS与CD3+、CD4+、NK呈现负相关，与CD8+呈现正相关。健康状况中的PF、RP、GH、SF、MH与免疫功能各项指标均相关，除了与CD4+/CD8+呈负相关外，其余均呈正相关；BP、RE与CD3+、CD4+、CD8+、NK正相关；VT与CD3+、CD8+和NK正相关，与CD4+/CD8+负相关。结论： 1．乳腺癌患者的焦虑、抑郁、自评健康状况水平与免疫功能有一定关系。 2．本研究建立的综合性心理干预模式，可显著改善围手术期乳腺癌患者的焦虑和抑郁状况，并提高其自评健康状况和免疫功能。
关键词	乳腺癌围手术期心理状况心理干预免疫功能
学位类型	硕士
语种	中文
学位授予单位	中国科学院心理研究所
学位授予地点	心理研究所
文献类型	学位论文
条目标识符	http://ir.psych.ac.cn/handle/311026/4404
专题	中国科学院心理研究所回溯数据库(1956-2010)
推荐引用方式 GB/T 7714	杨秀木. 心理干预对围手术期乳腺癌患者情绪、自评健康及免疫功能的影响研究[D]. 心理研究所. 中国科学院心理研究所,2008.

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