| 其他摘要 | Objective: Diabetes is a worldwide non-infectious disease that seriously threatens human health. In recent years, the prevalence rate is rising sharply. A number of studies have shown that diabetes affects the cognitive function of patients. The purpose of this study is to explore the relationship between Diabetes mellitus type 2 (T2DM) related indicators and lifestyle (physical activity, intellectual and social activity participation, social support, etc.) and cognitive function in the elderly. To provide a basis for lifestyle intervention to improve cognitive function of the elderly with type 2 diabetes.Methods: A total of 132 elderly patients with type 2 diabetes[61 males, 71 females, mean age (66.26 ± 5.45) years] were selected from the internal medicine outpatient department of a community hospital in Beijing. Includes general information questionnaire and evaluated the patients in the elderly (PASE), and other physical activity scale general situation, disease condition and way of life, the immediate and delayed recall words, digit span, verbal fluency, digital countdown task cognitive assessment, with the sum of five cognitive task standard score for general cognitive ability. Single factor analysis and multiple linear regression analysis were used to explore the relationship between lifestyle and cognitive function.Results: Univariate analysis showed that: (1) In terms of general information, there were statistically significant differences in the scores of immediate and delayed recall and verbal fluency tasks in elderly type 2 diabetes patients of different ages (ps < 0.05); There were statistically significant differences in the performance of immediate and delayed recall tasks among the elderly type 2 diabetes patients of different genders (ps < 0.05). There were statistically significant differences in the five cognitive tasks among elderly type 2 diabetes patients with different educational levels (ps < 0.001).(2) In terms of diabetes-related factors, there were statistically significant differences in number span, verbal fluency and number countdown task scores among elderly type 2 diabetes patients with different knowledge of diabetes (ps < 0.05); There was significant difference in hBA1c content in elderly patients with type 2 diabetes mellitus (ps < 0.05). In elderly type 2 diabetes patients with different levels of fasting blood glucose and 2 hours postprandial blood glucose, there was statistically significant difference in immediate recall scores (ps < 0.05). (3) In terms of lifestyle factors, sleep, smoking, drinking and physical activity had no statistical significance on the five cognitive scores (ps > 0.05). Eating more eggs, milk and fruit was associated with cognitive ability. Eating eggs had statistical significance on the numeral-reciprocal task performance, eating milk had statistical significance on the word fluency task performance, and eating fruit had statistical significance on the immediate and delayed recall task performance (ps < 0.05). The difference between intellectual and social activities on all cognitive tasks was statistically significant (ps < 0.001); There were statistically significant differences in the scores of the five cognitive tasks among the elderly type 2 diabetes patients with different social support (ps < 0.05). Multiple regression analysis showed that Junior school/technical secondary school education or above, female, medium and more intelligence and social activities, and more social support were positively correlated with instant recall task performance (ps < 0.05). High school/technical secondary school education or above, female, medium/more social support positively correlated with delayed recall task performance (ps < 0.05); High school/technical secondary school education or above, more intelligence and social activities were positively correlated with number breadth task performance (ps < 0.05); Junior high school or above education, more intelligence and social activities, medium/high social support positively correlated with verbal fluency task performance (ps < 0.05); Junior high school and above education, more intellectual and social activities, more social support were positively correlated with numerically reciprocal task performance (ps < 0.05); The education of junior high school or above, moderate/more intelligence and social activities, more social support and overall cognitive ability were positively correlated (ps < 0.05).Conclusion: Active blood glucose control is beneficial to cognitive function in elderly patients with type 2 diabetes, and more intellectual activities, social participation and social support may be lifestyle protective factors for cognitive function in elderly patients with type 2 diabetes. |
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