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Alternative Titleneural mechanism of morphine-induced neuroadaptation with the involvement of noradrenalin
Thesis Advisor隋南
Degree Grantor中国科学院心理研究所
Place of Conferral心理研究所
Degree Discipline基础心理学
Keyword神经适应性变化 α受体 内侧前额叶 伏隔核 精神兴奋性 新颖寻求

    2前额叶皮质注射a1受体的拮抗剂prazosin能降低未接触过吗啡(naive )的大鼠的精神兴奋性,但不能降低吗啡戒断大鼠的精神兴奋性;同时降低大鼠的新颖寻求行为;

Other Abstract

    That relapse still exists even after prolonged withdrawal is a difficult issue in the medical cure of drug addiction. Neuro-adaptation induced by prolonged exposure to addictive drugs is the neural mechanisms of both compulsive drug seeking and relapse.Neuro-adaptation caused by addictive drugs increases the individuals' response to drugs and on the other hand, it reduces the response to natural reward in withdrawn individuals.There must be common neural mechanisms between the co-existing phenomena, and there must also be unique neural mechanisms in the drugs.To reveal the neuro-adaptation arising in the process from random, controllable drug-use to uncontrollable compulsive drug seeking  is of great significance both theoretically and practically.Based on the above hypothesis, in order to reveal the function of alpha adrenergic receptor in compulsive drug-seeking motivation during the process  of  drug  addiction,  using  sensitization  of  morphine-induced psychomotor activity as behavioral model, through the method of behavioral pharmacology, the neural mechanisms of alpha  adrenergic  receptor's involvement in the process of addiction has been studied.The adjustment function caused by alpha receptors in medial prefrontal cortex and nucleus accumbens to morphine-induced psychomotor activity has been compared in tfie period of first use of drugs and in repetitive-use period. Furthermore, the effect on novelty seeking caused by alpha-receptors in relevant brain areas has also been compared.
Major results are as follow:
    1 After prolonged morphine exposure, rats' response to morphine-induced psychomotor activity is strengthened and response to novel object induced reward weakened.
    2 Injection of prazosin in medial prefrontal cortex will block morphine-induced psychomotor activity of naive rats,  however, it will not block hat of morphine-withdrawn rats, but it will block the novelty seeking behavior of morphine-withdrawn rats.
    3 Injection of clonidine in medial prefrontal cortex will block morphine-induced psychomotor effect of both naive rats and morphine-withdrawn rats, and will block the novelty seeking behavior of morphine-withdrawn rats.
    4 Injection of prazosin in nucleus accumbens will not affect the morphine-induced psychomotor effect of either naive rats or morphine-withdrawn rats, nor will it affect the novelty seeking behavior of morphine-withdrawn rats.
    5 Injection of clonidine in nucleus accumbens will block morphine-induced psychomotor  effect  of  naive  rats,  however,  it  will  not  block  that  of morphine-withdrawn rats, nor will it affect the novelty seeking behavior of morphine-withdrawn rats.
These results show:
    1 The weakening of the function of alpha1 receptors in medial prefrontal cortex and alpha2 receptors in nucleus accumbens caused by repetitive exposure to morphine is probably the cause of compulsive drug-seeking activity.
    2 Blocking alpha1 receptors in medial prefrontal cortex accelerates the loss of interest in nafiiral reward after mnrnhine withdrawal.
    3 Blocking alpha2 receptors in medial prefrontal cortex not only restrains drug-seeking motivation, but also blocks the individual's seeking motivation for novelty stimulus, which suggests that, while selecting medicine for curing addiction, it should be considered to reduce the influence on natural reward as much as possible and to avoid major side-effect.

Subject Area心理学
Document Type学位论文
Recommended Citation
GB/T 7714
王冬梅. 去甲肾上腺素参与吗啡神经适应性改变的中枢机制[D]. 心理研究所. 中国科学院心理研究所,2007.
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