Intermittent hypoxia training effectively protects against cognitive decline caused by acute hypoxia exposure

doi:10.1007/s00424-023-02885-x

PSYCH OpenIR

	Intermittent hypoxia training effectively protects against cognitive decline caused by acute hypoxia exposure
	Zhang, Guangbo 1,2; Yang, Guochun 3; Zhou, Yanzhao 1; Cao, Zhengtao 4; Yin, Ming 5; Ma, Lin 5; Fan, Ming 1,2,6; Zhao, Yong-Qi 1,7; Zhu, Lingling 1,6,7
通讯作者	Zhao, Yong-Qi(yqzhaoprc@sina.com) ; Zhu, Lingling(linglingzhuamms@126.com)
摘要	Intermittent hypoxia training (IHT) is a promising approach that has been used to induce acclimatization to hypoxia and subsequently lower the risk of developing acute mountain sickness (AMS). However, the effects of IHT on cognitive and cerebrovascular function after acute hypoxia exposure have not been characterized. In the present study, we first confirmed that the simplified IHT paradigm was effective at relieving AMS at 4300 m. Second, we found that IHT improved participants' cognitive and neural alterations when they were exposed to hypoxia. Specifically, impaired working memory performance, decreased conflict control function, impaired cognitive control, and aggravated mental fatigue induced by acute hypoxia exposure were significantly alleviated in the IHT group. Furthermore, a reversal of brain swelling induced by acute hypoxia exposure was visualized in the IHT group using magnetic resonance imaging. An increase in cerebral blood flow (CBF) was observed in multiple brain regions of the IHT group after hypoxia exposure as compared with the control group. Based on these findings, the simplified IHT paradigm might facilitate hypoxia acclimatization, alleviate AMS symptoms, and increase CBF in multiple brain regions, thus ameliorating brain swelling and cognitive dysfunction.
关键词	Intermittent hypoxia Cognitive function Magnetic resonance imaging Cerebral blood flow Acute mountain sickness
	2023-11-23
语种	英语
DOI	10.1007/s00424-023-02885-x
发表期刊	PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
ISSN	0031-6768
页码	14
收录类别	SCI
资助项目	Beijing Science and Technology Commission[Z161100000216134] ; Beijing Science and Technology Commission[7204283] ; Key Program of National Nature Sciences Foundation of China[81430044]
出版者	SPRINGER HEIDELBERG
WOS关键词	ACUTE MOUNTAIN-SICKNESS ; HIGH-ALTITUDE ; HIPPOCAMPAL NEUROGENESIS ; BRAIN ; CONFLICT ; MEMORY ; MECHANISMS
WOS研究方向	Physiology
WOS类目	Physiology
WOS记录号	WOS:001107252300001
资助机构	Beijing Science and Technology Commission ; Key Program of National Nature Sciences Foundation of China
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/46512
通讯作者	Zhao, Yong-Qi; Zhu, Lingling
作者单位	1.Beijing Inst Basic Med Sci, Dept Cognit Sci & Stress Med, 27 Taiping Rd, Beijing, Peoples R China 2.Capital Med Univ, Beijing Inst Brain Disorders, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China 4.PLA, AF Med Ctr, Beijing, Peoples R China 5.Peoples Liberat Army Gen Hosp, Med Ctr Chinese 1, Beijing, Peoples R China 6.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China 7.Anhui Med Univ, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Guangbo,Yang, Guochun,Zhou, Yanzhao,et al. Intermittent hypoxia training effectively protects against cognitive decline caused by acute hypoxia exposure[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY,2023:14.
APA	Zhang, Guangbo.,Yang, Guochun.,Zhou, Yanzhao.,Cao, Zhengtao.,Yin, Ming.,...&Zhu, Lingling.(2023).Intermittent hypoxia training effectively protects against cognitive decline caused by acute hypoxia exposure.PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY,14.
MLA	Zhang, Guangbo,et al."Intermittent hypoxia training effectively protects against cognitive decline caused by acute hypoxia exposure".PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2023):14.