心理行为因素、免疫功能与乳腺癌的相关性研究
刘艳
学位类型硕士
导师林文娟
1998
学位授予单位中国科学院心理研究所
学位授予地点中国科学院心理研究所
学位专业生物心理学
关键词心理行为因素 免疫功能 心理行为干预 乳腺癌
摘要本研究以乳腺癌患者为被试,通过问卷调查和免疫测试法探讨了乳腺癌患者心理行为因素、免疫功能及肿瘤间的关系。实验分两部分:实验一探讨患者的人格、情绪与肿瘤分期和免疫功能间的关系;实验二探讨心理行为干预对乳腺癌患者情绪及免疫功能的影响。结果发现,晚期的患者情绪稳定性较强并表现出较多的焦虑情绪;外向的患者自然杀伤细胞(natural killer cells, NK)活性较高;内向的患者搏斗精神较弱并且表现出较多的失望情绪;宿命倾向越强的患者NK细胞活性和唾液免疫球蛋白A (immunoglobulin A, IgA)水平越高;搏斗精神越强的患者唾液IgA水平越高;心理行为干预可以改善放疗中患者的焦虑情绪,促进NK细胞活性和外周血淋巴细胞数增加。
其他摘要Present study consists of two experiments. In the first experiment, the relationship between psycho-behavioral factors, immune function and the stage of breast cancer was investigated. Fifty six postoperated hospitalized breast cancer patients with radiotherapy were used as the subjects. EPQ and MAC questionnaires were used to assess the patients' psycho-behavioral factors. Blood NK activation level and saliva IgA level were determined as the assessment of their immune function. It was found that the late stage breast cancer patients were more stable but more anxious in emotion. Patients with extrovert personality had higher NK activation and higher fighting spirit than did the patients with introvert personality. The patients with more fatalism had higher levels of saliva IgA and NK activation than did the patients with less fatalism. It was also found that the higher the level of saliva IgA, the higher the level of fighting spirit. In the second experiment, the effect of psycho-behavioral intervention on the immune function and the emotional state of these patients was studied. It was found that the psycho-behavioral intervention significantly increased the level of NK activation and tended to decrease the level of anxious preoccupation. The number of the patients who had to use medicine to increase peripheral blood white cells during radiotherapy was significantly decreased in patients with psycho-behavioral therapy when compared with the control group. Collectively, the data suggested that the immune function, cancer stage were related to the patients' psycho-behavioral factors and the psycho-behavioral intervention could improve the patients' immune function and emotional state.
页数43
语种中文
文献类型学位论文
条目标识符http://ir.psych.ac.cn/handle/311026/4818
专题中国科学院心理研究所回溯数据库(1956-2010)
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刘艳. 心理行为因素、免疫功能与乳腺癌的相关性研究[D]. 中国科学院心理研究所. 中国科学院心理研究所,1998.
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