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Differential activity in left inferior frontal gyrus for pseudowords and real words: An event-related fMRI study on auditory lexical decision
Xiao, ZW; Zhang, JX; Wang, XY; Wu, RH; Hu, XP; Weng, XC; Tan, LH; Z. W. Xiao
2005-06-01
Source PublicationHUMAN BRAIN MAPPING
ISSN1065-9471
SubtypeArticle
Volume25Issue:2Pages:212-221
AbstractAfter Newman and Twieg ([2001]: Hum Brain Mapp 14:39-47) and others, we used a fast event-related functional magnetic resonance imaging (fMRI) design and contrasted the lexical processing of pseudowords and real words. Participants carried out an auditory lexical decision task on a list of randomly intermixed real and pseudo Chinese two-character (or two-syllable) words. The pseudowords were constructed by recombining constituent characters of the real words to control for sublexical code properties. Processing of pseudowords and real words activated a highly comparable network of brain regions, including bilateral inferior frontal gyrus, superior, middle temporal gyrus, calcarine and lingual gyrus, and left supramarginal gyrus. Mirroring a behavioral lexical effect, left inferior frontal gyrus (IFG) was significantly more activated for pseudowords than for real words. This result disconfirms a popular view that this area plays a role in grapheme-to-phoneme conversion, as such a conversion process was unnecessary in our task with auditory stimulus presentation. An alternative view was supported that attributes increased activity in left IFG for pseudowords to general processes in decision making, specifically in making positive versus negative responses. Activation in left supramarginal gyrus was of a much larger volume for real words than for pseudowords, suggesting a role of this region in the representation of phonological or semantic information for two-character Chinese words at the lexical level.; After Newman and Twieg ([2001]: Hum Brain Mapp 14:39-47) and others, we used a fast event-related functional magnetic resonance imaging (fMRI) design and contrasted the lexical processing of pseudowords and real words. Participants carried out an auditory lexical decision task on a list of randomly intermixed real and pseudo Chinese two-character (or two-syllable) words. The pseudowords were constructed by recombining constituent characters of the real words to control for sublexical code properties. Processing of pseudowords and real words activated a highly comparable network of brain regions, including bilateral inferior frontal gyrus, superior, middle temporal gyrus, calcarine and lingual gyrus, and left supramarginal gyrus. Mirroring a behavioral lexical effect, left inferior frontal gyrus (IFG) was significantly more activated for pseudowords than for real words. This result disconfirms a popular view that this area plays a role in grapheme-to-phoneme conversion, as such a conversion process was unnecessary in our task with auditory stimulus presentation. An alternative view was supported that attributes increased activity in left IFG for pseudowords to general processes in decision making, specifically in making positive versus negative responses. Activation in left supramarginal gyrus was of a much larger volume for real words than for pseudowords, suggesting a role of this region in the representation of phonological or semantic information for two-character Chinese words at the lexical level. (c) 2005 Wiley-Liss, Inc.
Keywordlexical decision auditory inferior frontal gyrus fMRI pseudowords Chinese
Subject Area心理语言学 ; 认知神经科学
Indexed BySCI
Language英语
WOS IDWOS:000229194500002
Citation statistics
Cited Times:70[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5317
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorZ. W. Xiao
Affiliation1.Shantou Univ, Coll Med, Mol Imaging Res Ctr, Shantou, Peoples R China
2.Univ Hong Kong, Dept Psychol, Hong Kong, Hong Kong, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing, Peoples R China
4.Shantou Univ, Affiliated Hosp 2, Coll Med, Shantou, Peoples R China
5.Georgia Tech, Caulter Dept Biomed Engn, Atlanta, GA USA
6.Emory Univ, Atlanta, GA 30322 USA
7.Univ Hong Kong, Dept Linguist, Hong Kong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Xiao, ZW,Zhang, JX,Wang, XY,et al. Differential activity in left inferior frontal gyrus for pseudowords and real words: An event-related fMRI study on auditory lexical decision[J]. HUMAN BRAIN MAPPING,2005,25(2):212-221.
APA Xiao, ZW.,Zhang, JX.,Wang, XY.,Wu, RH.,Hu, XP.,...&Z. W. Xiao.(2005).Differential activity in left inferior frontal gyrus for pseudowords and real words: An event-related fMRI study on auditory lexical decision.HUMAN BRAIN MAPPING,25(2),212-221.
MLA Xiao, ZW,et al."Differential activity in left inferior frontal gyrus for pseudowords and real words: An event-related fMRI study on auditory lexical decision".HUMAN BRAIN MAPPING 25.2(2005):212-221.
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