Differential activity in left inferior frontal gyrus for pseudowords and real words: An event-related fMRI study on auditory lexical decision

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	Differential activity in left inferior frontal gyrus for pseudowords and real words: An event-related fMRI study on auditory lexical decision
	Xiao, ZW ; Zhang, JX; Wang, XY ; Wu, RH ; Hu, XP ; Weng, XC; Tan, LH ; Z. W. Xiao
摘要	After Newman and Twieg ([2001]: Hum Brain Mapp 14:39-47) and others, we used a fast event-related functional magnetic resonance imaging (fMRI) design and contrasted the lexical processing of pseudowords and real words. Participants carried out an auditory lexical decision task on a list of randomly intermixed real and pseudo Chinese two-character (or two-syllable) words. The pseudowords were constructed by recombining constituent characters of the real words to control for sublexical code properties. Processing of pseudowords and real words activated a highly comparable network of brain regions, including bilateral inferior frontal gyrus, superior, middle temporal gyrus, calcarine and lingual gyrus, and left supramarginal gyrus. Mirroring a behavioral lexical effect, left inferior frontal gyrus (IFG) was significantly more activated for pseudowords than for real words. This result disconfirms a popular view that this area plays a role in grapheme-to-phoneme conversion, as such a conversion process was unnecessary in our task with auditory stimulus presentation. An alternative view was supported that attributes increased activity in left IFG for pseudowords to general processes in decision making, specifically in making positive versus negative responses. Activation in left supramarginal gyrus was of a much larger volume for real words than for pseudowords, suggesting a role of this region in the representation of phonological or semantic information for two-character Chinese words at the lexical level.; After Newman and Twieg ([2001]: Hum Brain Mapp 14:39-47) and others, we used a fast event-related functional magnetic resonance imaging (fMRI) design and contrasted the lexical processing of pseudowords and real words. Participants carried out an auditory lexical decision task on a list of randomly intermixed real and pseudo Chinese two-character (or two-syllable) words. The pseudowords were constructed by recombining constituent characters of the real words to control for sublexical code properties. Processing of pseudowords and real words activated a highly comparable network of brain regions, including bilateral inferior frontal gyrus, superior, middle temporal gyrus, calcarine and lingual gyrus, and left supramarginal gyrus. Mirroring a behavioral lexical effect, left inferior frontal gyrus (IFG) was significantly more activated for pseudowords than for real words. This result disconfirms a popular view that this area plays a role in grapheme-to-phoneme conversion, as such a conversion process was unnecessary in our task with auditory stimulus presentation. An alternative view was supported that attributes increased activity in left IFG for pseudowords to general processes in decision making, specifically in making positive versus negative responses. Activation in left supramarginal gyrus was of a much larger volume for real words than for pseudowords, suggesting a role of this region in the representation of phonological or semantic information for two-character Chinese words at the lexical level. (c) 2005 Wiley-Liss, Inc.
关键词	lexical decision auditory inferior frontal gyrus fMRI pseudowords Chinese
学科领域	心理语言学 ; 认知神经科学
	2005-06-01
语种	英语
发表期刊	HUMAN BRAIN MAPPING
ISSN	1065-9471
卷号	25 期号:2 页码:212-221
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000229194500002
引用统计	被引频次：93[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/5317
专题	中国科学院心理研究所回溯数据库(1956-2010)
通讯作者	Z. W. Xiao
作者单位	1.Shantou Univ, Coll Med, Mol Imaging Res Ctr, Shantou, Peoples R China 2.Univ Hong Kong, Dept Psychol, Hong Kong, Hong Kong, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Lab Higher Brain Funct, Beijing, Peoples R China 4.Shantou Univ, Affiliated Hosp 2, Coll Med, Shantou, Peoples R China 5.Georgia Tech, Caulter Dept Biomed Engn, Atlanta, GA USA 6.Emory Univ, Atlanta, GA 30322 USA 7.Univ Hong Kong, Dept Linguist, Hong Kong, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Xiao, ZW,Zhang, JX,Wang, XY,et al. Differential activity in left inferior frontal gyrus for pseudowords and real words: An event-related fMRI study on auditory lexical decision[J]. HUMAN BRAIN MAPPING,2005,25(2):212-221.
APA	Xiao, ZW.,Zhang, JX.,Wang, XY.,Wu, RH.,Hu, XP.,...&Z. W. Xiao.(2005).Differential activity in left inferior frontal gyrus for pseudowords and real words: An event-related fMRI study on auditory lexical decision.HUMAN BRAIN MAPPING,25(2),212-221.
MLA	Xiao, ZW,et al."Differential activity in left inferior frontal gyrus for pseudowords and real words: An event-related fMRI study on auditory lexical decision".HUMAN BRAIN MAPPING 25.2(2005):212-221.

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