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| Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits | |
Huo,Lijuan1,2; Lu,Xiaobing1,2; Wu,Fengchun1,2; Chang,Catherine3; Ning,Yuping1,2,4; Zhang,Xiang Yang1,5
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| 第一作者 | Huo,Lijuan |
| 心理所单位排序 | 5 |
| 摘要 | AbstractBackgroundDespite inconsistent findings, accumulative evidence has shown abnormalities of the key antioxidant enzyme, superoxide dismutase (SOD), in patients with schizophrenia. However, few studies explored SOD in late-life schizophrenia (LLS). Our work aimed to investigate changes in SOD activity and the relationship between SOD activity and psychotic symptoms or cognitive deficits in LLS.Methods32 geriatric male patients with schizophrenia (age?≥?60) and 28 age-matched male normal controls were recruited in the study. We assessed cognitive functions with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), evaluated the severity of clinical symptoms with the Positive and Negative Syndrome Scale (PANSS), and measured the plasma levels of SOD.ResultsPatients with LLS presented with higher total levels of SOD compared to the controls (81.70 vs. 65.26?U/ml, p? |
| 关键词 | Geriatric schizophrenia Oxidative stress Plasma Cognition Negative symptoms |
| 2021-12-04 | |
| 语种 | 英语 |
| DOI | 10.1186/s12888-021-03604-5 |
| 发表期刊 | BMC Psychiatry (IF:4.400[JCR-2022],4.900[5-Year]) |
| 卷号 | 21期号:1页码:10 |
| 期刊论文类型 | 实证研究 |
| 收录类别 | SCI |
| 资助项目 | National Natural Science Foundation of China[82102673] ; Science and Technology Plan Project of Guangdong Province, China[2019B030316001] ; Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory, Science and Technology Program of Guangzhou, China[201805010009] ; Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory, Science and Technology Program of Guangzhou, China[201807010064] |
| 出版者 | BioMed Central |
| WOS关键词 | ANTIOXIDANT DEFENSE SYSTEMS ; ACID REACTIVE SUBSTANCES ; DRUG-NAIVE PATIENTS ; OXIDATIVE STRESS ; LIPID-PEROXIDATION ; NEUROPSYCHOLOGICAL PERFORMANCE ; NEGATIVE SYMPTOMS ; BIPOLAR DISORDER ; DNA-DAMAGE ; IMPAIRMENT |
| WOS研究方向 | Psychiatry |
| WOS类目 | Psychiatry |
| WOS记录号 | BMC:10.1186/s12888-021-03604-5 |
| WOS分区 | Q2 |
| 资助机构 | National Natural Science Foundation of China ; Science and Technology Plan Project of Guangdong Province, China ; Guangzhou Municipal Psychiatric Disease Clinical Transformation Laboratory, Science and Technology Program of Guangzhou, China |
| 引用统计 | 正在获取...
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| 文献类型 | 期刊论文 |
| 条目标识符 | https://ir.psych.ac.cn/handle/311026/41095 |
| 专题 | 中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang,Xiang Yang |
| 作者单位 | 1.Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital); Department of Psychiatry 2.Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders 3.The University of Texas Health Science Center at Houston; Department of Psychiatry and Behavioral Sciences 4.Southern Medical University; The First School of Clinical Medicine 5.Institute of Psychology, Chinese Academy of Sciences; CAS Key Laboratory of Mental Health |
| 通讯作者单位 | 中国科学院心理研究所 |
| 推荐引用方式 GB/T 7714 | Huo,Lijuan,Lu,Xiaobing,Wu,Fengchun,et al. Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits[J]. BMC Psychiatry,2021,21(1):10. |
| APA | Huo,Lijuan,Lu,Xiaobing,Wu,Fengchun,Chang,Catherine,Ning,Yuping,&Zhang,Xiang Yang.(2021).Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits.BMC Psychiatry,21(1),10. |
| MLA | Huo,Lijuan,et al."Elevated activity of superoxide dismutase in male late-life schizophrenia and its correlation with clinical symptoms and cognitive deficits".BMC Psychiatry 21.1(2021):10. |
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