PSYCH OpenIR  > 中国科学院心理健康重点实验室
Anxiolytic-Like Effects of Compound Zhi Zhu Xiang in Rats
Wang, Yan-Li1; Shi, Jin-Li1; Yong, Liu1; Ren, Zhao2; Zhai, Yu-Jing1; Guo, Jian-You3; Shi, JL (reprint author), Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China.
2012
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
SubtypeArticle
Contribution Rank3
AbstractThe purpose of this study was to determine whether compound zhi zhu xiang (CZZX) exerts anxiolytic-like effects in rats. The animals were orally administered CZZX (0.75, 1.5, and 3 g/kg daily) for 10 days and tested in the elevated plus maze (EPM), Vogel conflict test (VCT), and open field. Repeated treatment with CZZX (3 g/kg/day, p.o.) significantly increased the percentage of both entries into and time spent on the open arms of the EPM compared with saline controls. In the VCT, repeated treatment with CZZX (1.5 and 3 g/kg/day, p.o.) significantly increased the number of punished licks. The drug did not change the total entries into the open arms of the EPM or interfere with water consumption or nociceptive threshold, discarding potential confounding factors in the two tests. In the open field, locomotion was not reduced, discarding the possible sedative effect of CZZX. In the binding assay, the binding of [H-3] Ro 15-1788 (flumazenil) to the benzodiazepine binding site in washed crude synaptosomal membranes from rat cerebral cortex was affected by CZZX. These data indicate an anxiolytic-like profile of action for CZZX without sedative side effects, and this activity may be mediated by benzodiazepine binding site modulation at.-aminobutyric acid-A receptors.
Subject AreaEmotional Psychology,medical Psychology
URL查看原文
Indexed BySCI
Language英语
Funding OrganizationMinistry of Science and Technology [2009ZX09103-381, 2012ZX09102-201-018] ; Key Laboratory of Mental Health, Chinese Academy of Sciences, NNSF [30800301, 31170992] ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8] ; Beijing University of Chinese Medicine [2011JYB22XS-072, 2011JYB22XS-039]
Project Intro.This work was supported by the Key New Drugs Innovation project from Ministry of Science and Technology (2009ZX09103-381, 2012ZX09102-201-018), the project from Key Laboratory of Mental Health, Chinese Academy of Sciences, NNSF grant (30800301, 31170992), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18, and KSCX2-EW-J-8), and Autonomous Project of Graduate Program from Beijing University of Chinese Medicine (2011JYB22XS-072, 2011JYB22XS-039).
WOS IDWOS:000305058400001
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/11408
Collection中国科学院心理健康重点实验室
Corresponding AuthorShi, JL (reprint author), Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China.
Affiliation1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
2.Yunnan Inst Mat Med, Yunnan 650111, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Wang, Yan-Li,Shi, Jin-Li,Yong, Liu,et al. Anxiolytic-Like Effects of Compound Zhi Zhu Xiang in Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012.
APA Wang, Yan-Li.,Shi, Jin-Li.,Yong, Liu.,Ren, Zhao.,Zhai, Yu-Jing.,...&Shi, JL .(2012).Anxiolytic-Like Effects of Compound Zhi Zhu Xiang in Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Wang, Yan-Li,et al."Anxiolytic-Like Effects of Compound Zhi Zhu Xiang in Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012).
Files in This Item:
File Name/Size DocType Version Access License
WOS000305058400001.p(1090KB) 限制开放CC BY-NC-SAView Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Yan-Li]'s Articles
[Shi, Jin-Li]'s Articles
[Yong, Liu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Yan-Li]'s Articles
[Shi, Jin-Li]'s Articles
[Yong, Liu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Yan-Li]'s Articles
[Shi, Jin-Li]'s Articles
[Yong, Liu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: WOS000305058400001.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.