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Anxiolytic-Like Effects of Compound Zhi Zhu Xiang in Rats
Wang, Yan-Li1; Shi, Jin-Li1; Yong, Liu1; Ren, Zhao2; Zhai, Yu-Jing1; Guo, Jian-You3; Shi, JL (reprint author), Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China.
2012
发表期刊EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
文章类型Article
产权排序3
摘要The purpose of this study was to determine whether compound zhi zhu xiang (CZZX) exerts anxiolytic-like effects in rats. The animals were orally administered CZZX (0.75, 1.5, and 3 g/kg daily) for 10 days and tested in the elevated plus maze (EPM), Vogel conflict test (VCT), and open field. Repeated treatment with CZZX (3 g/kg/day, p.o.) significantly increased the percentage of both entries into and time spent on the open arms of the EPM compared with saline controls. In the VCT, repeated treatment with CZZX (1.5 and 3 g/kg/day, p.o.) significantly increased the number of punished licks. The drug did not change the total entries into the open arms of the EPM or interfere with water consumption or nociceptive threshold, discarding potential confounding factors in the two tests. In the open field, locomotion was not reduced, discarding the possible sedative effect of CZZX. In the binding assay, the binding of [H-3] Ro 15-1788 (flumazenil) to the benzodiazepine binding site in washed crude synaptosomal membranes from rat cerebral cortex was affected by CZZX. These data indicate an anxiolytic-like profile of action for CZZX without sedative side effects, and this activity may be mediated by benzodiazepine binding site modulation at.-aminobutyric acid-A receptors.
学科领域Emotional Psychology,medical Psychology
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收录类别SCI
语种英语
项目资助者Ministry of Science and Technology [2009ZX09103-381, 2012ZX09102-201-018] ; Key Laboratory of Mental Health, Chinese Academy of Sciences, NNSF [30800301, 31170992] ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8] ; Beijing University of Chinese Medicine [2011JYB22XS-072, 2011JYB22XS-039]
项目简介This work was supported by the Key New Drugs Innovation project from Ministry of Science and Technology (2009ZX09103-381, 2012ZX09102-201-018), the project from Key Laboratory of Mental Health, Chinese Academy of Sciences, NNSF grant (30800301, 31170992), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18, and KSCX2-EW-J-8), and Autonomous Project of Graduate Program from Beijing University of Chinese Medicine (2011JYB22XS-072, 2011JYB22XS-039).
WOS记录号WOS:000305058400001
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/11408
专题中国科学院心理健康重点实验室
通讯作者Shi, JL (reprint author), Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China.
作者单位1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
2.Yunnan Inst Mat Med, Yunnan 650111, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Wang, Yan-Li,Shi, Jin-Li,Yong, Liu,et al. Anxiolytic-Like Effects of Compound Zhi Zhu Xiang in Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012.
APA Wang, Yan-Li.,Shi, Jin-Li.,Yong, Liu.,Ren, Zhao.,Zhai, Yu-Jing.,...&Shi, JL .(2012).Anxiolytic-Like Effects of Compound Zhi Zhu Xiang in Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Wang, Yan-Li,et al."Anxiolytic-Like Effects of Compound Zhi Zhu Xiang in Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012).
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