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Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory
Barral, S.1,2; Bird, T.3,4; Goate, A.5; Farlow, M. R.6; Diaz-Arrastia, R.8; Bennett, D. A.9; Graff-Radford, N.10; Boeve, B. F.11; Sweet, R. A.12; Stern, Y.1,2; Wilson, R. S.9; Foroud, T.7; Ott, J.13; Mayeux, R.1,2; Natl Inst Aging Late-Onset Alzheim; Mayeux, R (reprint author), Columbia Univ Coll Phys & Surg, Gertrude H Sergievsky Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, 630 W 168th St, New York, NY 10032 USA.
2012-05-01
Source PublicationNEUROLOGY
ISSN0028-3878
SubtypeArticle
Volume78Issue:19Pages:1464-1471
AbstractObjective: Several genome-wide association studies (GWAS) have associated variants in late-onset Alzheimer disease (LOAD) susceptibility genes; however, these single nucleotide polymorphisms (SNPs) have very modest effects, suggesting that single SNP approaches may be inadequate to identify genetic risks. An alternative approach is the use of multilocus genotype patterns (MLGPs) that combine SNPs at different susceptibility genes.
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
Funding OrganizationNIH [HHSN268200782096C] ; NIA [U24AG26396, U24AG021886, R01AG17917, P50AG8702, P30AG10161, P30AG013846, P30AG028377, P30AG010133, P50AG05134, P50AG016574] ; NSFC from the Chinese Government [30730057] ; Alzheimer Disease Genetic Consortium ; Athena Diagnostics, Inc. ; AstraZeneca ; Genetech ; Pfizer ; Danone Research ; Elan Pharma ; Eli Lilly ; Novartis ; OctaPharma ; sanofi-aventis ; Sonexa Therapeutics ; Eisai ; Medivation ; Janssen ; Allon ; Forest ; Cephalon Inc. ; Allon Pharmaceuticals ; Mangurian Foundation ; Alzheimer Association ; Behavioral Neurology of Dementia ; Rush University Medical Center ; Natural Science Foundation of China ; N I A [P50AG05138, P30AG013854, P30AG08017, P50AG016582, P50AG016570, P30AG028383, P30AG010124, P50AG005133, R01AG027224, P50AG05142, P30AG012300, P50AG05136, P50AG05681]
Project Intro.Supported by NIH and NIA grants U24AG26396, U24AG021886, R01AG17917, P50AG8702, P30AG10161, P30AG013846, P30AG028377, P30AG010133, P50AG05134, P50AG016574, P50AG05138, P30AG013854, P30AG08017, P50AG016582, P50AG016570, P30AG028383, P30AG010124, P50AG005133, R01AG027224, P50AG05142, P30AG012300, P50AG05136, and P50AG05681 and NSFC grant 30730057 from the Chinese Government to J. Ott. Genotyping services were provided by the Center for Inherited Disease Research (CIDR). CIDR is fully funded through a federal contract from the NIH to The Johns Hopkins University (contract HHSN268200782096C). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript, but did review the manuscript before submission.Dr. Barral receives research support from Alzheimer Disease Genetic Consortium. Dr. Bird receives research support from Athena Diagnostics, Inc. Dr. Goate serves as consultant for AstraZeneca; serves as an expert testimony for Howrey & Associates; receives research support from AstraZeneca, Genetech, Pfizer, and NIA; and holds patent royalties from Taconic (Tau mutation patent). Dr. Farlow serves as a board member for Medivation, Merck, and INC Res/Toyama; serves as a consultant for Accera, Astellas, Baxter, Bristol Meyers Squibb, GE Healthcare, Novartis, Pfizer, Prana, and sanofi-aventis; serves as an expert testimony for Pfizer; receives research support from Danone Research, Elan Pharma, Eli Lilly, Novartis, Genetech, OctaPharma, Pfizer, sanofi-aventis, Sonexa Therapeutics, Eisai, and NIA; holds a patent from Elan and patent royalties from UpTo-Date; and holds stock options from QR Pharm and MedAvante. Dr. Diaz-Arrastia receives research support from NIH. Dr. Bennett receives research support from NIH. Dr. Graff-Radford serves as board member of The Neurologist; serves as a consultant for Codman; and receives research support from Medivation, Janssen, Allon, Forest, and NIA. Dr. Boeve receives research support from Cephalon Inc., Allon Pharmaceuticals, Mangurian Foundation, Alzheimer Association, and NIH; receives royalties as a co-editor of Behavioral Neurology of Dementia; and receives support for development of educational presentations from the American Academy of Neurology. Dr. Sweet receives research support from NIH. Dr. Stern serves as consultant for Allergan Inc., Cephalon Inc., Elan Corporation, Eisai Inc., Pfizer, Ortho-McNeil Neurologics, Merck Serono, GlaxoSmithKline, Eli Lilly, Janssen, and NIH. Dr. Wilson receives research support from a grant from Rush University Medical Center. Dr. Foroud receives research support from NIH. Dr. Ott receives research support from Natural Science Foundation of China. Dr. Mayeux receives research support from NIH. Go to Neurology. org for full disclosures.
WOS IDWOS:000303776900007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/12833
Collection中国科学院心理健康重点实验室
Corresponding AuthorMayeux, R (reprint author), Columbia Univ Coll Phys & Surg, Gertrude H Sergievsky Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, 630 W 168th St, New York, NY 10032 USA.
Affiliation1.Columbia Univ Coll Phys & Surg, Gertrude H Sergievsky Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA
2.Columbia Univ Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA
3.Univ Washington, Geriatr Res Educ & Clin Ctr, Vet Affairs Puget Sound Hlth Care Syst, Seattle Div, Seattle, WA 98195 USA
4.Univ Washington, Dept Neurol, Seattle, WA 98195 USA
5.Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
6.Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN USA
7.Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN USA
8.Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA
9.Rush Univ, Rush Alzheimers Dis Ctr, Med Ctr, Chicago, IL 60612 USA
10.Mayo Clin, Dept Neurol, Coll Med, Jacksonville, FL 32224 USA
11.Mayo Clin, Dept Neurol, Rochester, MN USA
12.Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA
13.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Barral, S.,Bird, T.,Goate, A.,et al. Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory[J]. NEUROLOGY,2012,78(19):1464-1471.
APA Barral, S..,Bird, T..,Goate, A..,Farlow, M. R..,Diaz-Arrastia, R..,...&Mayeux, R .(2012).Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.NEUROLOGY,78(19),1464-1471.
MLA Barral, S.,et al."Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory".NEUROLOGY 78.19(2012):1464-1471.
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