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| Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory | |
| Barral, S.1,2; Bird, T.3,4; Goate, A.5; Farlow, M. R.6; Diaz-Arrastia, R.8; Bennett, D. A.9; Graff-Radford, N.10; Boeve, B. F.11; Sweet, R. A.12; Stern, Y.1,2; Wilson, R. S.9; Foroud, T.7; Ott, J.13; Mayeux, R.1,2; Natl Inst Aging Late-Onset Alzheim; Mayeux, R (reprint author), Columbia Univ Coll Phys & Surg, Gertrude H Sergievsky Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, 630 W 168th St, New York, NY 10032 USA. | |
| 摘要 | Objective: Several genome-wide association studies (GWAS) have associated variants in late-onset Alzheimer disease (LOAD) susceptibility genes; however, these single nucleotide polymorphisms (SNPs) have very modest effects, suggesting that single SNP approaches may be inadequate to identify genetic risks. An alternative approach is the use of multilocus genotype patterns (MLGPs) that combine SNPs at different susceptibility genes. |
| 学科领域 | Medical Psychology |
| 2012-05-01 | |
| 语种 | 英语 |
| 发表期刊 | NEUROLOGY
 |
| ISSN | 0028-3878 |
| 卷号 | 78期号:19页码:1464-1471 |
| 期刊论文类型 | Article |
| URL | 查看原文 |
| 收录类别 | SCI |
| 项目简介 | Supported by NIH and NIA grants U24AG26396, U24AG021886, R01AG17917, P50AG8702, P30AG10161, P30AG013846, P30AG028377, P30AG010133, P50AG05134, P50AG016574, P50AG05138, P30AG013854, P30AG08017, P50AG016582, P50AG016570, P30AG028383, P30AG010124, P50AG005133, R01AG027224, P50AG05142, P30AG012300, P50AG05136, and P50AG05681 and NSFC grant 30730057 from the Chinese Government to J. Ott. Genotyping services were provided by the Center for Inherited Disease Research (CIDR). CIDR is fully funded through a federal contract from the NIH to The Johns Hopkins University (contract HHSN268200782096C). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript, but did review the manuscript before submission.Dr. Barral receives research support from Alzheimer Disease Genetic Consortium. Dr. Bird receives research support from Athena Diagnostics, Inc. Dr. Goate serves as consultant for AstraZeneca; serves as an expert testimony for Howrey & Associates; receives research support from AstraZeneca, Genetech, Pfizer, and NIA; and holds patent royalties from Taconic (Tau mutation patent). Dr. Farlow serves as a board member for Medivation, Merck, and INC Res/Toyama; serves as a consultant for Accera, Astellas, Baxter, Bristol Meyers Squibb, GE Healthcare, Novartis, Pfizer, Prana, and sanofi-aventis; serves as an expert testimony for Pfizer; receives research support from Danone Research, Elan Pharma, Eli Lilly, Novartis, Genetech, OctaPharma, Pfizer, sanofi-aventis, Sonexa Therapeutics, Eisai, and NIA; holds a patent from Elan and patent royalties from UpTo-Date; and holds stock options from QR Pharm and MedAvante. Dr. Diaz-Arrastia receives research support from NIH. Dr. Bennett receives research support from NIH. Dr. Graff-Radford serves as board member of The Neurologist; serves as a consultant for Codman; and receives research support from Medivation, Janssen, Allon, Forest, and NIA. Dr. Boeve receives research support from Cephalon Inc., Allon Pharmaceuticals, Mangurian Foundation, Alzheimer Association, and NIH; receives royalties as a co-editor of Behavioral Neurology of Dementia; and receives support for development of educational presentations from the American Academy of Neurology. Dr. Sweet receives research support from NIH. Dr. Stern serves as consultant for Allergan Inc., Cephalon Inc., Elan Corporation, Eisai Inc., Pfizer, Ortho-McNeil Neurologics, Merck Serono, GlaxoSmithKline, Eli Lilly, Janssen, and NIH. Dr. Wilson receives research support from a grant from Rush University Medical Center. Dr. Foroud receives research support from NIH. Dr. Ott receives research support from Natural Science Foundation of China. Dr. Mayeux receives research support from NIH. Go to Neurology. org for full disclosures. |
| WOS记录号 | WOS:000303776900007 |
| 资助机构 | NIH [HHSN268200782096C] ; NIA [U24AG26396, U24AG021886, R01AG17917, P50AG8702, P30AG10161, P30AG013846, P30AG028377, P30AG010133, P50AG05134, P50AG016574] ; NSFC from the Chinese Government [30730057] ; Alzheimer Disease Genetic Consortium ; Athena Diagnostics, Inc. ; AstraZeneca ; Genetech ; Pfizer ; Danone Research ; Elan Pharma ; Eli Lilly ; Novartis ; OctaPharma ; sanofi-aventis ; Sonexa Therapeutics ; Eisai ; Medivation ; Janssen ; Allon ; Forest ; Cephalon Inc. ; Allon Pharmaceuticals ; Mangurian Foundation ; Alzheimer Association ; Behavioral Neurology of Dementia ; Rush University Medical Center ; Natural Science Foundation of China ; N I A [P50AG05138, P30AG013854, P30AG08017, P50AG016582, P50AG016570, P30AG028383, P30AG010124, P50AG005133, R01AG027224, P50AG05142, P30AG012300, P50AG05136, P50AG05681] |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/12833 |
| 专题 | 中国科学院心理健康重点实验室 |
| 通讯作者 | Mayeux, R (reprint author), Columbia Univ Coll Phys & Surg, Gertrude H Sergievsky Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, 630 W 168th St, New York, NY 10032 USA. |
| 作者单位 | 1.Columbia Univ Coll Phys & Surg, Gertrude H Sergievsky Ctr, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA 2.Columbia Univ Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA 3.Univ Washington, Geriatr Res Educ & Clin Ctr, Vet Affairs Puget Sound Hlth Care Syst, Seattle Div, Seattle, WA 98195 USA 4.Univ Washington, Dept Neurol, Seattle, WA 98195 USA 5.Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA 6.Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN USA 7.Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN USA 8.Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA 9.Rush Univ, Rush Alzheimers Dis Ctr, Med Ctr, Chicago, IL 60612 USA 10.Mayo Clin, Dept Neurol, Coll Med, Jacksonville, FL 32224 USA 11.Mayo Clin, Dept Neurol, Rochester, MN USA 12.Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA 13.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Barral, S.,Bird, T.,Goate, A.,et al. Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory[J]. NEUROLOGY,2012,78(19):1464-1471. |
| APA | Barral, S..,Bird, T..,Goate, A..,Farlow, M. R..,Diaz-Arrastia, R..,...&Mayeux, R .(2012).Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory.NEUROLOGY,78(19),1464-1471. |
| MLA | Barral, S.,et al."Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory".NEUROLOGY 78.19(2012):1464-1471. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| WOS_000303776900007.（360KB） | 限制开放 | Apache License | 请求全文 | |||
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