|Alternative Title||Study of functional magnetic resonance imaging repeatability of linguistic-functional cortex|
|王美豪1; 汪娟2; 黄梓芮3; 陈兵4; 戴睿5; 王维卓2; 翁旭初6; 程敬亮1|
Objective To explore the reproducibility and stability of brain functional area in the response of language tasks during Chinese word processing with functional magnetic resonance imaging (fMRI) by follow-up scanning so as to provide rationales for clinical preoperative localization and the mechanisms of recovery from aphasia. Methods The fMRI data were collected by scanning semantic and phonologic judgments in 15 healthy volunteers. Each subject was scanned twice by the same fMRI procedure of both language tasks with an interval of 1 month. By analyzing the effective overlapping average activation maps, the reproducibility of inter-subject imaging result for two language tasks were estimated by selecting the main language areas, such as Broca' s area and Wernicke' s area as the region of interest (ROI). By individually calculating the spatial distance of ROI centroid coordinates in the same activating range before and after test, the inter-subject stability in between-session was calculated quantitatively. Results Both language tasks activated more than one language-related brain areas in cerebral hemispheres. Both language tasks induced significant BOLD response in Broca' s and Wernicke's areas with a tendency of left lateralization. The number of subjects in terms of the activation of both language tasks in Broca' s and Wernicke's areas accounted over a half of the total subjects. As compared with the phonologic judgment task, the semantic judgment task showed better reproducibility in Broca's area. In the same spatial distance of ROI centroid coordinates, the stability of Broca's area was higher than that of Wernicke's area while the stability of semantic judgment in Broca' s area higher than that of phonologic judgment. Conclusion Such main language domains as Broca's and Wernicke's areas can be effectively activated by both semantic and phonologic judgments. By comparison, semantic )udgment in Broca' s area shows a higher level of reproducibility and stability. Thus it is applicable for clinical preoperative localization and the mechanisms of recovery from aphasia.
|Keyword||磁共振成像 语言 可重复性 结果 Broca区|
|王美豪,汪娟,黄梓芮,等. 语言功能脑区功能磁共振可重复性观察[J]. 中华医学杂志,2012,92(35):共4页.|
|MLA||王美豪,et al."语言功能脑区功能磁共振可重复性观察".中华医学杂志 92.35(2012):共4页.|
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