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Alternative TitleNormative Brain Development in Chinese Han Poputation: MRI templates and Growth Charts
Thesis Advisor左西年
Degree Grantor中国科学院大学
Place of Conferral中国科学院心理研究所
Degree Name理学博士
Degree Discipline认知神经科学
Keyword儿童脑模板 脑网络图谱 脑发育 生长曲线 磁共振成像 学龄儿童


Other Abstract

As the largest population in the world, Chinese lack age一specific standard templates for reference on their neurodevelopment while such normative brain templates are widely used in Magnetic Resonance Imaging (MRI) studies for brain image processing and statistical comparisons across different individuals.

Here, we constructed age-speck brain templates based on 674 Chinese MRI data of school-aged typically developing children (TDC). The age-specific templates at one-year interval are estimated by using Advanced Normalization Tools. First, we employed other two independent imaging datasets (84 TDC) to derive the warp cost modeled as a function of age differences between individual brains and template brail}s, resulting a strong U-shape of this cost function and validating the necessity of use of the age-specific templates. Second, normative curves are modeled for volumes of different brain tissues during school ages. Nearly linear shrink of gray mattes; lineai0 enlarging of cerebral spinal fluid, and a strong nonlinear trajectory of white matter reaching its peak between 12-13 years old are detected. Accordingly, more wide-age brain templates were also generated for children (6-12 yrs) and adolescents (13-18 yrs). Based on the resting-state functional MRI data from Chinese Color Nest Project (CCNP), which employed accelerated longitudinal designs for modeling brain and behavioral trajectories, we further constructed cortical functional network atlas for Chinese children and adolescents. By optimizing the reducibility of functional networks, it is revealed that five and nine highly reproducible networks detected in Chinese children and adolescents' population respectively During cortical development, frontoparietal and limbic networks occurs in adolescents, also the limbic and default mode networks get separated, and sub-system become divided within default mode networks.

These findings not only provide resources of Chinese age-specific brain templates but also reveal neurobiologically meaningful nonnative trajectories and cortical function networks of brain development for Chinese children and adolescents. which are potentially useful for future applications requiring references on eurodevelopment in healthy samples (e.g., growth charts, educational and medical practice).

Document Type学位论文
Recommended Citation
GB/T 7714
董昊铭. 中国汉族学龄几童标准脑和生长曲线研究[D]. 中国科学院心理研究所. 中国科学院大学,2018.
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