Transcranial alternating current stimulation for treating depression: a randomized controlled trial

doi:10.1093/brain/awab252

	Transcranial alternating current stimulation for treating depression: a randomized controlled trial
	Wang, Hongxing 1,2; Wang, Kun 1,3; Xue, Qing 1; Peng, Mao 1; Yin, Lu 4; Gu, Xuecun 3; Leng, Haixia 1; Lu, Juan 3; Liu, Hongzhi 3; Wang, Di 3; Xiao, Jin 3; Sun, Zhichao 1; Li, Ning 1; Dong, Kai 1; Zhang, Qian 1; Zhan, Shuqin 1; Fan, Chunqiu 1; Min, Baoquan 1; Zhou, Aihong 1; Xie, Yunyan 1; Song, Haiqing 1; Ye, Jing 1; Liu, Aihua 1; Gao, Ran 1; Huang, Liyuan 1; Jiao, Lidong 1; Song, Yang 1; Dong, Huiqing 1; Tian, Zichen 5; Si, Tianmei 6,7; Zhang, Xiangyang8 ; Li, Xinmin 9; Kamiya, Atsushi 10; Cosci, Fiammetta 11; Gao, Keming 12; Wang, Yuping 1
通讯作者	Wang, Hongxing(wanghongxing@xwh.ccmu.edu.cn) ; Wang, Yuping(wangyuping01@sina.cn)
摘要	Treatment of depression with antidepressants is partly effective. Transcranial alternating current stimulation can provide a non-pharmacological alternative for adult patients with major depressive disorder. However, no study has used the stimulation to treat first-episode and drug-naive patients with major depressive disorder. We used a randomized, double-blind, sham-controlled design to examine the clinical efficacy and safety of the stimulation in treating first-episode drug-naive patients in a Chinese Han population. From 4 June 2018 to 30 December 2019, 100 patients were recruited and randomly assigned to receive 20 daily 40-min, 77.5 Hz, 15 mA, one forehead and two mastoid sessions of active or sham stimulation (n = 50 for each group) in four consecutive weeks (Week 4), and were followed for additional 4-week efficacy/safety assessment without stimulation (Week 8). The primary outcome was a remission rate defined as the 17-item Hamilton Depression Rating Scale (HDRS-17) score <= 7 at Week 8. Secondary analyses were response rates (defined as a reduction of >= 50% in the HDRS-17), changes in depressive symptoms and severity from baseline to Week 4 and Week 8, and rates of adverse events. Data were analysed in an intention-to-treat sample. Forty-nine in the active and 46 in the sham completed the study. Twenty-seven of 50 (54%) in the active treatment group and 9 of 50 (18%) in the sham group achieved remission at the end of Week 8. The remission rate was significantly higher in the active group compared to that in the sham group with a risk ratio of 1.78 (95% confidence interval, 1.29, 2.47). Compared with the sham, the active group had a significantly higher remission rate at Week 4, response rates at Weeks 4 and 8, and a larger reduction in depressive symptoms from baseline to Weeks 4 and 8. Adverse events were similar between the groups. In conclusion, the stimulation on the frontal cortex and two mastoids significantly improved symptoms in first-episode drug-naive patients with major depressive disorder and may be considered as a non-pharmacological intervention for them in an outpatient setting. In a randomized double-blind controlled trial, Wang et al. show that 4 weeks of treatment with transcranial alternating current stimulation (tACS) reduces symptoms to a greater degree than sham stimulation in first-episode drug-naive patients with major depressive disorder.
关键词	drug-naive efficacy first-episode major depressive disorder transcranial alternating current stimulation
	2022-03-29
语种	英语
DOI	10.1093/brain/awab252
发表期刊	BRAIN
ISSN	0006-8950
卷号	145 期号:1 页码:83-91
收录类别	SCI
资助项目	National Key R&D Program of China[2017YFC1310001] ; National Key R&D Program of China[2016YFC1307000] ; National Natural Science Foundation of China[81771862] ; Beijing Municipal Science and Technology Project[Z171100000117016] ; Beijing Natural Science Foundation[KZ201710025017] ; Beijing Municipal Hospital Research and Development Plan[PX2017069] ; Beijing Hundred, Thousand, and Ten Thousand Talents Project[2017-CXYF-09]
出版者	OXFORD UNIV PRESS
WOS关键词	CRANIAL ELECTROTHERAPY STIMULATION ; ELECTRICAL-STIMULATION ; MAJOR DEPRESSION ; DOUBLE-BLIND ; FOLLOW-UP ; EFFICACY ; SAFETY ; PERCEPTION ; DISORDER ; INSOMNIA
WOS研究方向	Neurosciences & Neurology
WOS类目	Clinical Neurology ; Neurosciences
WOS记录号	WOS:000775227900011
资助机构	National Key R&D Program of China ; National Natural Science Foundation of China ; Beijing Municipal Science and Technology Project ; Beijing Natural Science Foundation ; Beijing Municipal Hospital Research and Development Plan ; Beijing Hundred, Thousand, and Ten Thousand Talents Project
引用统计	被引频次：35[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/42367
专题	中国科学院心理健康重点实验室
通讯作者	Wang, Hongxing; Wang, Yuping
作者单位	1.Capital Med Univ, Xuanwu Hosp,Natl Clin Res Ctr Geriatr Dis, Beijing Psychosomat Dis Consultat Ctr,Dept Neurol, Natl Ctr Neurol Disorders,Div Neuropsychiat & Psy, 45 Changchun St, Beijing 100053, Peoples R China 2.Capital Med Univ, Ctr Epilepsy, Inst Sleep & Consciousness Disorders, Beijing Inst Brain Disorders, Beijing 100053, Peoples R China 3.Beijing Puren Hosp, Dept Neurol, Beijing 100062, Peoples R China 4.Peking Union Med Coll & Chinese Acad Med Sci, Fuwai Hosp, Med Res & Biometr Ctr, Natl Ctr Cardiovasc Dis, Beijing, Peoples R China 5.Carleton Coll, Dept Biol, Northfield, MN 55057 USA 6.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Natl Clin Res Ctr Mental Disorders,Peking Univ Si, Beijing 100191, Peoples R China 7.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China 8.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 9.Univ Alberta, Fac Med & Dent, Dept Psychiat, Edmonton, AB T6G 2B7, Canada 10.Johns Hopkins Univ, Dept Psychiat & Behav Sci, Sch Med, Baltimore, MD 21287 USA 11.Univ Florence, Dept Hlth Sci, I-50135 Florence, Italy 12.Case Western Reserve Univ, Sch Med, Dept Psychiat, Cleveland, OH 44106 USA
推荐引用方式 GB/T 7714	Wang, Hongxing,Wang, Kun,Xue, Qing,et al. Transcranial alternating current stimulation for treating depression: a randomized controlled trial[J]. BRAIN,2022,145(1):83-91.
APA	Wang, Hongxing.,Wang, Kun.,Xue, Qing.,Peng, Mao.,Yin, Lu.,...&Wang, Yuping.(2022).Transcranial alternating current stimulation for treating depression: a randomized controlled trial.BRAIN,145(1),83-91.
MLA	Wang, Hongxing,et al."Transcranial alternating current stimulation for treating depression: a randomized controlled trial".BRAIN 145.1(2022):83-91.

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