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Morphine modulation of pain processing in medial and lateral pain pathways
Wang, Jin-Yan1; Huang, Jin2; Chang, Jing-Yu3; Woodward, Donald J.3; Luo, Fei1; Fei Luo
2009-10-13
Source PublicationMOLECULAR PAIN
ISSN1744-8069
SubtypeArticle
Volume5
AbstractBackground: Despite the wide-spread use of morphine and related opioid agonists in clinic and their powerful analgesic effects, our understanding of the neural mechanisms underlying opioid analgesia at supraspinal levels is quite limited. The present study was designed to investigate the modulative effect of morphine on nociceptive processing in the medial and lateral pain pathways using a multiple single-unit recording technique. Pain evoked neuronal activities were simultaneously recorded from the primary somatosensory cortex (SI), ventral posterolateral thalamus (VPL), anterior cingulate cortex (ACC), and medial dorsal thalamus (MD) with eight-wire microelectrode arrays in awake rats. Results: The results showed that the noxious heat evoked responses of single neurons in all of the four areas were depressed after systemic injection of 5 mg/kg morphine. The depressive effects of morphine included (i) decreasing the neuronal response magnitude; (ii) reducing the fraction of responding neurons, and (iii) shortening the response duration. In addition, the capability of cortical and thalamic neural ensembles to discriminate noxious from innocuous stimuli was decreased by morphine within both pain pathways. Meanwhile, morphine suppressed the pain-evoked changes in the information flow from medial to lateral pathway and from cortex to thalamus. These effects were completely blocked by pre-treatment with the opiate receptor antagonist naloxone. Conclusion: These results suggest that morphine exerts analgesic effects through suppressing both sensory and affective dimensions of pain.; Background: Despite the wide-spread use of morphine and related opioid agonists in clinic and their powerful analgesic effects, our understanding of the neural mechanisms underlying opioid analgesia at supraspinal levels is quite limited. The present study was designed to investigate the modulative effect of morphine on nociceptive processing in the medial and lateral pain pathways using a multiple single-unit recording technique. Pain evoked neuronal activities were simultaneously recorded from the primary somatosensory cortex (SI), ventral posterolateral thalamus (VPL), anterior cingulate cortex (ACC), and medial dorsal thalamus (MD) with eight-wire microelectrode arrays in awake rats.
Subject Area认知神经科学 ; 医学心理学
Indexed BySCI
Language英语
WOS IDWOS:000271609900001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/5555
Collection中国科学院心理研究所回溯数据库(1956-2010)
Corresponding AuthorFei Luo
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
3.Neurosci Res Inst N Carolina, Winston Salem, NC USA
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Jin-Yan,Huang, Jin,Chang, Jing-Yu,et al. Morphine modulation of pain processing in medial and lateral pain pathways[J]. MOLECULAR PAIN,2009,5.
APA Wang, Jin-Yan,Huang, Jin,Chang, Jing-Yu,Woodward, Donald J.,Luo, Fei,&Fei Luo.(2009).Morphine modulation of pain processing in medial and lateral pain pathways.MOLECULAR PAIN,5.
MLA Wang, Jin-Yan,et al."Morphine modulation of pain processing in medial and lateral pain pathways".MOLECULAR PAIN 5(2009).
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