Institutional Repository, Institute of Psychology, Chinese Academy of Sciences
| Morphine modulation of pain processing in medial and lateral pain pathways | |
Wang, Jin-Yan1 ; Huang, Jin2; Chang, Jing-Yu3; Woodward, Donald J.3; Luo, Fei1; Fei Luo
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| 2009-10-13 | |
| Source Publication | MOLECULAR PAIN
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| ISSN | 1744-8069 |
| Subtype | Article |
| Volume | 5 |
| Abstract | Background: Despite the wide-spread use of morphine and related opioid agonists in clinic and their powerful analgesic effects, our understanding of the neural mechanisms underlying opioid analgesia at supraspinal levels is quite limited. The present study was designed to investigate the modulative effect of morphine on nociceptive processing in the medial and lateral pain pathways using a multiple single-unit recording technique. Pain evoked neuronal activities were simultaneously recorded from the primary somatosensory cortex (SI), ventral posterolateral thalamus (VPL), anterior cingulate cortex (ACC), and medial dorsal thalamus (MD) with eight-wire microelectrode arrays in awake rats. Results: The results showed that the noxious heat evoked responses of single neurons in all of the four areas were depressed after systemic injection of 5 mg/kg morphine. The depressive effects of morphine included (i) decreasing the neuronal response magnitude; (ii) reducing the fraction of responding neurons, and (iii) shortening the response duration. In addition, the capability of cortical and thalamic neural ensembles to discriminate noxious from innocuous stimuli was decreased by morphine within both pain pathways. Meanwhile, morphine suppressed the pain-evoked changes in the information flow from medial to lateral pathway and from cortex to thalamus. These effects were completely blocked by pre-treatment with the opiate receptor antagonist naloxone. Conclusion: These results suggest that morphine exerts analgesic effects through suppressing both sensory and affective dimensions of pain.; Background: Despite the wide-spread use of morphine and related opioid agonists in clinic and their powerful analgesic effects, our understanding of the neural mechanisms underlying opioid analgesia at supraspinal levels is quite limited. The present study was designed to investigate the modulative effect of morphine on nociceptive processing in the medial and lateral pain pathways using a multiple single-unit recording technique. Pain evoked neuronal activities were simultaneously recorded from the primary somatosensory cortex (SI), ventral posterolateral thalamus (VPL), anterior cingulate cortex (ACC), and medial dorsal thalamus (MD) with eight-wire microelectrode arrays in awake rats. |
| Subject Area | 认知神经科学 ; 医学心理学 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000271609900001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/5555 |
| Collection | 中国科学院心理研究所回溯数据库(1956-2010) |
| Corresponding Author | Fei Luo |
| Affiliation | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China 3.Neurosci Res Inst N Carolina, Winston Salem, NC USA |
| First Author Affilication | Key Laboratory of Mental Health, CAS |
| Recommended Citation GB/T 7714 | Wang, Jin-Yan,Huang, Jin,Chang, Jing-Yu,et al. Morphine modulation of pain processing in medial and lateral pain pathways[J]. MOLECULAR PAIN,2009,5. |
| APA | Wang, Jin-Yan,Huang, Jin,Chang, Jing-Yu,Woodward, Donald J.,Luo, Fei,&Fei Luo.(2009).Morphine modulation of pain processing in medial and lateral pain pathways.MOLECULAR PAIN,5. |
| MLA | Wang, Jin-Yan,et al."Morphine modulation of pain processing in medial and lateral pain pathways".MOLECULAR PAIN 5(2009). |
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