Motivational deficits in effort-based decision making in individuals with subsyndromal depression, first-episode and remitted depression patients

	Motivational deficits in effort-based decision making in individuals with subsyndromal depression, first-episode and remitted depression patients
	Yang, Xin-Hua 1,2; Huang, Jia3 ; Zhu, Cui-Ying 2; Wang, Ye-Fei 1; Cheung, Eric F. C.4; Chan, Raymond C. K.3 ; Xie, Guang-rong 1
摘要	Anhedonia is a hallmark symptom of major depressive disorder (MDD). Preliminary findings suggest that anhedonia is characterized by reduced reward anticipation and motivation of obtaining reward. However, relatively little is known about reward-based decision-making in depression. We tested the hypothesis that anhedonia in MDD may reflect specific impairments in motivation on reward-based decision-making and the deficits might be associated with depressive symptoms severity. In study 1, individuals with and without depressive symptoms performed the modified version of the Effort Expenditure for Rewards Task (EEfRT), a behavioral measure of cost/benefit decision-making. In study 2, MDD patients, remitted MDD patients and healthy controls were recruited for the same procedures. We found evidence for decreased willingness to make effort for rewards among individuals with subsyndromal depression; the effect was amplified in MDD patients, but dissipated in patients with remitted depression. We also found that reduced anticipatory and consummatory pleasure predicted decreased willingness to expend efforts to obtain rewards in MDD patients. For individuals with subsyndromal depression, the impairments were correlated with anticipatory anhedonia but not consummatory anhedonia. These data offer novel evidence that motivational deficits in MDD are correlated with depression severity and predicted by self-reported anhedonia. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
关键词	Depression Effort-based Decision-making Motivation Anhedonia Reward
	2014-12-30
语种	英语
发表期刊	PSYCHIATRY RESEARCH
ISSN	0165-1781
卷号	220 期号:3 页码:874-882
期刊论文类型	Article
收录类别	SSCI
WOS记录号	WOS:000347361300021
引用统计	被引频次：167[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14257
专题	中国科学院心理健康重点实验室
作者单位	1.Cent S Univ, Natl Technol Inst Psychiat, Xiangya Hosp 2, Mental Hlth Inst,Key Lab Psychiat & Mental Hlth H, Changsha 410011, Hunan, Peoples R China 2.Hunan Agr Univ, Coll Business, Changsha, Hunan, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Yang, Xin-Hua,Huang, Jia,Zhu, Cui-Ying,et al. Motivational deficits in effort-based decision making in individuals with subsyndromal depression, first-episode and remitted depression patients[J]. PSYCHIATRY RESEARCH,2014,220(3):874-882.
APA	Yang, Xin-Hua.,Huang, Jia.,Zhu, Cui-Ying.,Wang, Ye-Fei.,Cheung, Eric F. C..,...&Xie, Guang-rong.(2014).Motivational deficits in effort-based decision making in individuals with subsyndromal depression, first-episode and remitted depression patients.PSYCHIATRY RESEARCH,220(3),874-882.
MLA	Yang, Xin-Hua,et al."Motivational deficits in effort-based decision making in individuals with subsyndromal depression, first-episode and remitted depression patients".PSYCHIATRY RESEARCH 220.3(2014):874-882.

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