PSYCH OpenIR  > 中国科学院心理健康重点实验室
Clustering of Schizotypal Features in Unaffected First-Degree Relatives of Schizophrenia Patients
Lui, Simon S. Y.1,2; Hung, Karen S. Y.2; Wang, Yi1; Ho, Karen K. Y.2; Yeung, Hera K. H.2; Wang, Ya1,3; Huang, Jia1,3; Gooding, Diane C.4,5; Cheung, Eric F. C.2; Chan, Raymond C. K.1,3
First AuthorLui, Simon S. Y.
Contribution Rank1

Meehl conceptualized schizotypy as the phenotypic manifestations of a neural integrative defect resulting from a schizophrenia diathesis. The majority of schizotypy studies recruited subjects from the general population and revealed a multidimensional construct. This 2-phase investigation first examined the clustering of schizotypy in 194 unaffected relatives of schizophrenia patients using the Chapman Psychosis Proneness scales and then directly compared the cognitive profiles of negative schizotypal individuals and positive schizotypal individuals with schizophrenia patients and controls. In the first phase, cluster analysis categorized 194 unaffected relatives of schizophrenia patients into positive schizotypy (n = 33), negative schizotypy (n = 66), mixed schizotypy (n = 27), and low schizotypy (n = 64). Positive schizotypal participants showed more self-report pleasure experiences than negative schizotypal participants, replicating earlier cluster analytic findings. In the second phase, 27 negative schizotypal individuals, 18 positive schizotypal individuals, 19 schizophrenia patients, and 29 controls were recruited. Although the groups were matched in terms of age, gender, and IQ, they differed significantly in cognitive profiles. While schizophrenia patients exhibited the broadest cognitive impairments, negative schizotypal participants exhibited visual memory, working memory, and verbal fluency impairments, and positive schizotypal participants exhibited logical memory, visual memory, working memory, and theory-of-mind impairments. Among people with familial risk of schizophrenia, individuals exhibiting positive rather than negative schizotypal features resembled schizophrenia patients in cognitive profiles. Using the psychometric-familial method to identify schizotypy, our findings support the heterogeneity of schizotypy as well as the potential utility of the positive schizotypy dimension in genetically high-risk individuals to predict the risk of developing schizophrenia.

KeywordSchizotypy First-degree Relatives Clustering Analysis Cognitions
Indexed BySCIE
Funding ProjectBeijing Training Project for Leading Talents in ST[Z151100000315020] ; National Key Research and Development Programme[2016YFC0906402] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Programme for Creative Research Teams[Y2CX131003] ; Vilas Faculty Mid-Career Investigator Award
WOS KeywordEmotional Expressivity Scale ; Mind Impairments ; Working-memory ; Performance ; Disorders ; Psychosis ; Family ; Symptomatology ; Endophenotypes ; Metaanalysis
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000448172600009
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA
5.Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA
First Author Affilication认知与发展心理学研究室
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Lui, Simon S. Y.,Hung, Karen S. Y.,Wang, Yi,et al. Clustering of Schizotypal Features in Unaffected First-Degree Relatives of Schizophrenia Patients[J]. SCHIZOPHRENIA BULLETIN,2018,44:S536-S546.
APA Lui, Simon S. Y..,Hung, Karen S. Y..,Wang, Yi.,Ho, Karen K. Y..,Yeung, Hera K. H..,...&Chan, Raymond C. K..(2018).Clustering of Schizotypal Features in Unaffected First-Degree Relatives of Schizophrenia Patients.SCHIZOPHRENIA BULLETIN,44,S536-S546.
MLA Lui, Simon S. Y.,et al."Clustering of Schizotypal Features in Unaffected First-Degree Relatives of Schizophrenia Patients".SCHIZOPHRENIA BULLETIN 44(2018):S536-S546.
Files in This Item:
File Name/Size DocType Version Access License
Clustering of Schizo(201KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Lui, Simon S. Y.]'s Articles
[Hung, Karen S. Y.]'s Articles
[Wang, Yi]'s Articles
Baidu academic
Similar articles in Baidu academic
[Lui, Simon S. Y.]'s Articles
[Hung, Karen S. Y.]'s Articles
[Wang, Yi]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lui, Simon S. Y.]'s Articles
[Hung, Karen S. Y.]'s Articles
[Wang, Yi]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.