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Clustering of Schizotypal Features in Unaffected First-Degree Relatives of Schizophrenia Patients
Lui, Simon S. Y.1,2; Hung, Karen S. Y.2; Wang, Yi1; Ho, Karen K. Y.2; Yeung, Hera K. H.2; Wang, Ya1,3; Huang, Jia1,3; Gooding, Diane C.4,5; Cheung, Eric F. C.2; Chan, Raymond C. K.1,3
First AuthorLui, Simon S. Y.
2018-11-01
Source PublicationSCHIZOPHRENIA BULLETIN
Correspondent Emailrckchan@psych.ac.cn
ISSN0586-7614
SubtypeArticle
Volume44Pages:S536-S546
Contribution Rank1
Abstract

Meehl conceptualized schizotypy as the phenotypic manifestations of a neural integrative defect resulting from a schizophrenia diathesis. The majority of schizotypy studies recruited subjects from the general population and revealed a multidimensional construct. This 2-phase investigation first examined the clustering of schizotypy in 194 unaffected relatives of schizophrenia patients using the Chapman Psychosis Proneness scales and then directly compared the cognitive profiles of negative schizotypal individuals and positive schizotypal individuals with schizophrenia patients and controls. In the first phase, cluster analysis categorized 194 unaffected relatives of schizophrenia patients into positive schizotypy (n = 33), negative schizotypy (n = 66), mixed schizotypy (n = 27), and low schizotypy (n = 64). Positive schizotypal participants showed more self-report pleasure experiences than negative schizotypal participants, replicating earlier cluster analytic findings. In the second phase, 27 negative schizotypal individuals, 18 positive schizotypal individuals, 19 schizophrenia patients, and 29 controls were recruited. Although the groups were matched in terms of age, gender, and IQ, they differed significantly in cognitive profiles. While schizophrenia patients exhibited the broadest cognitive impairments, negative schizotypal participants exhibited visual memory, working memory, and verbal fluency impairments, and positive schizotypal participants exhibited logical memory, visual memory, working memory, and theory-of-mind impairments. Among people with familial risk of schizophrenia, individuals exhibiting positive rather than negative schizotypal features resembled schizophrenia patients in cognitive profiles. Using the psychometric-familial method to identify schizotypy, our findings support the heterogeneity of schizotypy as well as the potential utility of the positive schizotypy dimension in genetically high-risk individuals to predict the risk of developing schizophrenia.

KeywordSchizotypy First-degree Relatives Clustering Analysis Cognitions
DOI10.1093/schbul/sby035
Indexed BySCIE
Language英语
Funding OrganizationBeijing Training Project for Leading Talents in ST ; National Key Research and Development Programme ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Programme for Creative Research Teams ; Vilas Faculty Mid-Career Investigator Award
Funding ProjectBeijing Training Project for Leading Talents in ST[Z151100000315020] ; National Key Research and Development Programme[2016YFC0906402] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Programme for Creative Research Teams[Y2CX131003] ; Vilas Faculty Mid-Career Investigator Award
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000448172600009
PublisherOXFORD UNIV PRESS
WOS KeywordEmotional Expressivity Scale ; Mind Impairments ; Working-memory ; Performance ; Disorders ; Psychosis ; Family ; Symptomatology ; Endophenotypes ; Metaanalysis
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27290
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA
5.Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA
Recommended Citation
GB/T 7714
Lui, Simon S. Y.,Hung, Karen S. Y.,Wang, Yi,et al. Clustering of Schizotypal Features in Unaffected First-Degree Relatives of Schizophrenia Patients[J]. SCHIZOPHRENIA BULLETIN,2018,44:S536-S546.
APA Lui, Simon S. Y..,Hung, Karen S. Y..,Wang, Yi.,Ho, Karen K. Y..,Yeung, Hera K. H..,...&Chan, Raymond C. K..(2018).Clustering of Schizotypal Features in Unaffected First-Degree Relatives of Schizophrenia Patients.SCHIZOPHRENIA BULLETIN,44,S536-S546.
MLA Lui, Simon S. Y.,et al."Clustering of Schizotypal Features in Unaffected First-Degree Relatives of Schizophrenia Patients".SCHIZOPHRENIA BULLETIN 44(2018):S536-S546.
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