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Clustering of Schizotypal Features in Unaffected First-Degree Relatives of Schizophrenia Patients
Lui, Simon S. Y.1,2; Hung, Karen S. Y.2; Wang, Yi1; Ho, Karen K. Y.2; Yeung, Hera K. H.2; Wang, Ya1,3; Huang, Jia1,3; Gooding, Diane C.4,5; Cheung, Eric F. C.2; Chan, Raymond C. K.1,3
2018-11-01
发表期刊SCHIZOPHRENIA BULLETIN
ISSN0586-7614
卷号44页码:S536-S546
摘要Meehl conceptualized schizotypy as the phenotypic manifestations of a neural integrative defect resulting from a schizophrenia diathesis. The majority of schizotypy studies recruited subjects from the general population and revealed a multidimensional construct. This 2-phase investigation first examined the clustering of schizotypy in 194 unaffected relatives of schizophrenia patients using the Chapman Psychosis Proneness scales and then directly compared the cognitive profiles of negative schizotypal individuals and positive schizotypal individuals with schizophrenia patients and controls. In the first phase, cluster analysis categorized 194 unaffected relatives of schizophrenia patients into positive schizotypy (n = 33), negative schizotypy (n = 66), mixed schizotypy (n = 27), and low schizotypy (n = 64). Positive schizotypal participants showed more self-report pleasure experiences than negative schizotypal participants, replicating earlier cluster analytic findings. In the second phase, 27 negative schizotypal individuals, 18 positive schizotypal individuals, 19 schizophrenia patients, and 29 controls were recruited. Although the groups were matched in terms of age, gender, and IQ, they differed significantly in cognitive profiles. While schizophrenia patients exhibited the broadest cognitive impairments, negative schizotypal participants exhibited visual memory, working memory, and verbal fluency impairments, and positive schizotypal participants exhibited logical memory, visual memory, working memory, and theory-of-mind impairments. Among people with familial risk of schizophrenia, individuals exhibiting positive rather than negative schizotypal features resembled schizophrenia patients in cognitive profiles. Using the psychometric-familial method to identify schizotypy, our findings support the heterogeneity of schizotypy as well as the potential utility of the positive schizotypy dimension in genetically high-risk individuals to predict the risk of developing schizophrenia.
关键词schizotypy first-degree relatives clustering analysis cognitions
DOI10.1093/schbul/sby035
语种英语
项目资助者Beijing Training Project for Leading Talents in ST ; National Key Research and Development Programme ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Programme for Creative Research Teams ; Vilas Faculty Mid-Career Investigator Award
资助项目Beijing Training Project for Leading Talents in ST[Z151100000315020] ; National Key Research and Development Programme[2016YFC0906402] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Programme for Creative Research Teams[Y2CX131003] ; Vilas Faculty Mid-Career Investigator Award
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000448172600009
出版者OXFORD UNIV PRESS
关键词[WOS]EMOTIONAL EXPRESSIVITY SCALE ; MIND IMPAIRMENTS ; WORKING-MEMORY ; PERFORMANCE ; DISORDERS ; PSYCHOSIS ; FAMILY ; SYMPTOMATOLOGY ; ENDOPHENOTYPES ; METAANALYSIS
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27290
专题中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.
作者单位1.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA
5.Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA
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GB/T 7714
Lui, Simon S. Y.,Hung, Karen S. Y.,Wang, Yi,et al. Clustering of Schizotypal Features in Unaffected First-Degree Relatives of Schizophrenia Patients[J]. SCHIZOPHRENIA BULLETIN,2018,44:S536-S546.
APA Lui, Simon S. Y..,Hung, Karen S. Y..,Wang, Yi.,Ho, Karen K. Y..,Yeung, Hera K. H..,...&Chan, Raymond C. K..(2018).Clustering of Schizotypal Features in Unaffected First-Degree Relatives of Schizophrenia Patients.SCHIZOPHRENIA BULLETIN,44,S536-S546.
MLA Lui, Simon S. Y.,et al."Clustering of Schizotypal Features in Unaffected First-Degree Relatives of Schizophrenia Patients".SCHIZOPHRENIA BULLETIN 44(2018):S536-S546.
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